Rol de la Mitocondria en la Sarcopenia. Verónica Rojas.
Rol de la Mitocondria en la Sarcopenia. Verónica Rojas.
Rol de la Mitocondria en la Sarcopenia. Verónica Rojas.
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II. Mutación <strong>de</strong>l ADN mitocondrial<br />
Mutaciones<br />
<strong>en</strong> el ADN<br />
Alteración <strong>en</strong><br />
<strong>la</strong> actividad<br />
CTE<br />
Alteración<br />
funcional y<br />
estructural<br />
<strong>en</strong> tejido<br />
muscu<strong>la</strong>r<br />
Años<br />
Mitochondrial DNA <strong>de</strong>letion mutations colocalize with segm<strong>en</strong>tal electron transport system abnormalities, muscle fiber<br />
atrophy, fiber splitting, and oxidative damage in sarcop<strong>en</strong>ia. Faseb J 2001<br />
Mitochondrial DNA- <strong>de</strong>letion mutations accumu<strong>la</strong>te intracellu<strong>la</strong>rly to <strong>de</strong>trim<strong>en</strong>tal levels in aged human skeletal muscle<br />
fibers. Am J Hum G<strong>en</strong>et 2006
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