Rol de la Mitocondria en la Sarcopenia. Verónica Rojas.
Rol de la Mitocondria en la Sarcopenia. Verónica Rojas.
Rol de la Mitocondria en la Sarcopenia. Verónica Rojas.
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En músculo esquelético:<br />
n La edad y el reposo predispon<strong>en</strong> a mayor<br />
daño oxidativo<br />
n El daño oxidativo se asocia a inf<strong>la</strong>mación,<br />
catabolismo proteico y m<strong>en</strong>or r<strong>en</strong>dimi<strong>en</strong>to<br />
muscu<strong>la</strong>r<br />
n El daño oxidativo mitocondrial induce <strong>la</strong><br />
apoptosis <strong>de</strong> miocitos y atrofia muscu<strong>la</strong>r<br />
Oxidative stress, chronic disease,and muscle wasting. Muscle Nerve.2007<br />
Oxidative protein damage is associated with poor grip str<strong>en</strong>gth among ol<strong>de</strong>r wom<strong>en</strong> livingin the community. J. Appl. Physiol 2007<br />
Age-re<strong>la</strong>ted activation of mitochondrial caspase-in<strong>de</strong>p<strong>en</strong><strong>de</strong>nt apoptotic signaling in rat gastrocnemiusmuscle. Mech Ageing Dev. 2008
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