20.01.2015 Views

Rol de la Mitocondria en la Sarcopenia. Verónica Rojas.

Rol de la Mitocondria en la Sarcopenia. Verónica Rojas.

Rol de la Mitocondria en la Sarcopenia. Verónica Rojas.

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I. Daño oxidativo<br />

Daño <strong>en</strong> macromolécu<strong>la</strong>s:<br />

• Bases nitrog<strong>en</strong>adas (ADN)<br />

• Acidos grasos (membranas)<br />

• Proteínas (receptores, canales)<br />

Free radical theory of aging. Triangle 1973<br />

The role of mitochondrial DNA mutations in aging and sarcop<strong>en</strong>ia: implications for the mitochondrial vicious cycle theory of<br />

aging. Exp. Gerontol 2008

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