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Rol de la Mitocondria en la Sarcopenia. Verónica Rojas.

Rol de la Mitocondria en la Sarcopenia. Verónica Rojas.

Rol de la Mitocondria en la Sarcopenia. Verónica Rojas.

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IV. Dinámica mitocondrial<br />

n Las mitocondrias son plásticas y móviles<br />

n La dinámica mitocondrial permite:<br />

Mant<strong>en</strong>er el equilibrio redox<br />

Preservar <strong>la</strong> integridad <strong>de</strong>l ADN<br />

Modu<strong>la</strong>r <strong>la</strong> muerte celu<strong>la</strong>r<br />

Mant<strong>en</strong>er <strong>la</strong> función mitocondrial<br />

n La p<strong>la</strong>sticidad disminuye con <strong>la</strong> edad<br />

n Esto es especialm<strong>en</strong>te relevante <strong>en</strong> el músculo<br />

Mitochondrial fusion is required for mtDNA stability in skeletalmuscle and tolerance of mtDNA mutations. Cell 2010<br />

Mitochondrial dynamics in mammalianhealth and disease. Physiol. Rev. 2009

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