SERION ELISAclassic - virion\serion

Pos: 1 /Arbeitsanl eitung en ELISA classi c/Gültig für nur ein Dokument/U pdate/U pdate: Echovirus @ 11\mod_1335249184703_18.doc @ 51044 @
Pos: 6 /Arbeitsanl eitung en ELISA classi c/Gültig für alle D okumente/ELISA cl assic/Allgemei ne T exte ELISA cl assic/Kapitelüberschrift "Diag nostische Bedeutung" @ 0\mod_1177351537598_18.doc @ 221 @ 1
Pos: classic/Allgemeine @ 4\mod_1255336385816_18.doc 2 /Arbeitsanleitungen Texte ELISA @ classic/Einleitung classic/Gültig 21165 @ für "Enzymimmunoassay"
alle Dokumente/ELISA
SERION ELISA classic Echovirus IgA/IgG/IgM
Enzyme-immunoassay for determination of human antibodies
for in vitro diagnostic use
Dokument/Bestellnummern/Echovirus: 0\mod_1188370705487_18.doc Pos: 3 /Arbeitsanleitungen ELISA @ 6809 classic/Gültig @ Bestellnummern für nur ein @
SERION ELISA classic Echovirus IgA Order Nr.: ESR135A
SERION ELISA classic Echovirus IgG Order Nr.: ESR135G
SERION ELISA classic Echovirus IgM Order Nr.: ESR135M
Pos: classic/Allgemeine 0\mod_1177351044007_18.doc 4 /Arbeitsanleitungen Texte ELISA @ 170 classic/Kapitelüberschrift classic/Gültig @ 1 für alle Dokumente/ELISA
"Anwendungsbereich" @
1 INTENDED USE
Pos: 5 /Arbeitsanl eitung en ELISA classi c/Gültig für nur ein Dokument/Anwendungsber eich/Echovirus: Anwendungsber eich @ 11\mod_1335164233519_18.doc @ 50667 @
The SERION ELISA classic Echovirus IgA, IgG and IgM tests are qualitative and
quantitative immunoassays for the demonstration of human antibodies, in serum or
plasma, directed against ECHO viruses. The differential detection of the different antibody
classes facilitates the confirmation of contact with the organism and supports the
categorisation of the disease stage.
2 DIAGNOSTIC RELEVANCE
Pos: 7 /Arbeitsanl eitung en ELISA classi c/Gültig für nur ein Dokument/Di agnostische Bedeutung/Echovir us: Diagnostische Bedeutung @ 11\mod_1335167509699_18.doc @ 50718 @
Coxsackieviruses A and B, as well as the ECHO viruses, have a worldwide distribution
and all belong to the Picornaviridae family, genus Enterovirus. These virus groups are
similar in their biological characteristics and epidemiology with a primarily faecal-oral
transmission strategy but also being capable of spread via aerosols. Person to person
transmission is mainly by smear infection with the portal of entry being either the
alimentary canal or the respiratory tract. The viruses reach the reticuloendothelial system
and other target organs such as the myocardium, meninges or skin, via the blood
circulation.
While infections in tropical areas tend to be all year round, in temperate zones infections
are at their peak in the summer months and decline in the autumn. Small children are most
often infected, however in non-immune older children and adults, infection can lead to
severe disease. The incubation time lies anywhere between 12 hours and 35 days.
Over 90 % of all Enterovirus infections are asymptomatic or result only in mild, short
duration general malaise affecting the upper respiratory tract, such as sore throat with or
without rhinitis which is often associated with fever. In adults symptoms may be
pharyngitis, tonsillitis and flu-like symptoms. In particular, ECHO viruses are responsible
for epidemics in new born children and babies with rhinitis, pharyngitis, bronchitis and
pneumonia in hospitals and other institutions.
ECHO viruses may cause a panoply of disease conditions, such as aseptic meningitis,
encephalitis, ataxia, Guillain-Barré-Syndrome, exanthema, diarrhoea, hepatitis and foetal
damage. Less frequently paralysis, epidemic myalgia, pericarditis, myocarditis may occur.
Individuals with congenital or induced immunodeficiency are prone to viral persistence
following infection which may lead to chronic diseases such as enteritis, arthritis, CNS
disease or chronic heart disease. The role that ECHO viruses play in the etiology of
juvenile diabetes mellitus (type1/IDMM) has been discussed in the literature.
english 2