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Foco cáncer de pulmón y oncología gastrointestinal

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Bevacizumab extends survival beyond historical <br />

benchmark of 1 year <br />

Probability of OS <br />

1.0 <br />

0.9 <br />

0.8 <br />

0.7 <br />

0.6 <br />

0.5 <br />

0.4 <br />

0.3 <br />

0.2 <br />

E4599 overall pa@ent popula@on <br />

HR<br />

(95% CI)<br />

CP<br />

(n=444)<br />

Bevacizumab<br />

15mg/kg + CP<br />

(n=434)<br />

0.79<br />

(0.67–0.92)<br />

p value 0.003<br />

Median OS<br />

(months) 10.3 12.3<br />

0.1 <br />

10.3 12.3 <br />

0 <br />

0 6 12 18 24 30 36 42 <br />

Dura@on of survival (months) <br />

Sandler, et al. NEJM 2006

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