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Tema 3 - Medic.ula.ve

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Akira Shizuo. Curr Opin Immunol, 2003, 15:5-11.<br />

Pasare C. And Medzhitov R. Curr OpinImmunol, 2003, 15:1-6.<br />

Goldstein DR. Curr Opin Immunol. 2004)<br />

Receptores<br />

Toll (TLR)<br />

• Reconocen bacterias, hongos y virus<br />

• Reconocimiento de motivos altamente conservados:<br />

patrones molec<strong>ula</strong>res asociados a patógenos<br />

(PAMPS)<br />

• 11 receptores Toll hasta ahora descritos (TLR1-11)<br />

11)<br />

• Dominio extracel<strong>ula</strong>r rico en leucina<br />

• Dominio intracitoplasmático<br />

tico similar al receptor de IL-<br />

1 (TIR)<br />

• Señalización n a través s de: MyD88, kinasa asociada al<br />

receptor de IL-1 1 (IRAK), factor asociado al receptor<br />

del TNF (TRAF), Map kinasas y (NF)-κB

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