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Untitled - Roche Trasplantes

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PROTOCOL BIOPSIES AND THE DIAGNOSIS OF HUMORAL REJECTION<br />

vent acute humoral allograft rejection. Protocol biopsies appear to be an adequate tool<br />

for monitoring the natural course of humoral immune responses and all prospective clinical<br />

trials testing new drugs for the treatment of manifest humoral rejection episodes<br />

should include protocol biopsies. Furthermore, protocol biopsies should also allow for a<br />

timely therapeutic intervention ones intragraft signs of accommodation and humoral rejection<br />

are adequately understood.<br />

REFERENCES<br />

1. Bohmig GA, Exner M, Habicht A, Schillinger M, Lang U, Kletzmayr J, et al. Capillary<br />

C4d deposition in kidney allografts: a specific marker of alloantibody-dependent graft<br />

injury. J Am Soc Nephrol 2002; 13 (4): 1091-9.<br />

2. Bohmig GA, Exner M, Watschinger B, Wenter C, Wahrmann M, Osterreicher C, et<br />

al. C4d deposits in renal allografts are associated with inferior graft outcome. Transplant<br />

Proc 2001; 33 (1-2): 1151-2.<br />

3. Colvin RB, Smith RN. Antibody-mediated organ-allograft rejection. Nat Rev Immunol<br />

2005; 5 (10): 807-17.<br />

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Vascular deposition of complement-split products in kidney allografts with cell-mediated<br />

rejection. Clin Exp Immunol 1991; 86 (3): 464-70.<br />

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Int 1993; 43 (6): 1333-8.<br />

6. Feucht HE, Lederer SR, Kluth B. Humoral alloreactivity in recipients of renal allografts<br />

as a risk factor for the development of delayed graft function. Transplantation 1998;<br />

65 (5): 757-8.<br />

7. Fidler ME, Gloor JM, Lager DJ, Larson TS, Griffin MD, Textor SC, et al. Histologic findings<br />

of antibody-mediated rejection in ABO blood-group-incompatible living-donor kidney<br />

transplantation. Am J Transplant 2004; 4 (1): 101-7.<br />

8. Fiebeler A, Mengel M, Merkel S, Haller H, Schwarz A. Diffuse C4d deposition and<br />

morphology of acute humoral rejection in a stable renal allograft. Transplantation 2003;<br />

76 (7): 1132-3.<br />

9. Halloran PF, Wadgymar A, Ritchie S, Falk J, Solez K, Srinivasa NS. The significance of<br />

the anti-class I antibody response. I. Clinical and pathologic features of anti-class I-<br />

mediated rejection. Transplantation 1990; 49 (1): 85-91.<br />

10. Halloran PF, Schlaut J, Solez K, Srinivasa NS. The significance of the anti-class I response.<br />

II. Clinical and pathologic features of renal transplants with anti-class I-like<br />

antibody. Transplantation 1992; 53 (3): 550-5.<br />

11. Herzenberg AM, Gill JS, Djurdjev O, Magil AB. C4d deposition in acute rejection: an<br />

independent long-term prognostic factor. J Am Soc Nephrol 2002; 13 (1): 234-41.<br />

12. Ivanyi B. Transplant capillaropathy and transplant glomerulopathy: ultrastructural markers<br />

of chronic renal allograft rejection. Nephrol Dial Transplant 2003; 18 (4): 655-60.<br />

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