Untitled - Roche Trasplantes
Untitled - Roche Trasplantes
Untitled - Roche Trasplantes
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PROTOCOL BIOPSIES AND THE DIAGNOSIS OF HUMORAL REJECTION<br />
Figure 6. Intimal accumulation of foam cells is the hallmark of chronic<br />
transplant vasculopathy and leads to lumen narrowing and decreased<br />
perfusion with chronic ischemia of the allograft. Additionally, myofibroblasts<br />
invade and proliferate in the subendothelial and intimal space.<br />
Figure 7. As a hint to a concomitant T-cell-mediated immunological<br />
pathogenesis of transplant vasculopathy sometimes scattered<br />
T-lymphocytes (positive for CD3 in the immunohistochemical reaction)<br />
can be found in the extended subendothelial space (arrows) adjacent<br />
to the foam cells.<br />
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