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Farmacología Clínica de la Patología Gástrica - caded

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EFECTOS TOXICOS<br />

<br />

Toxicidad aguda:<br />

En ratas 700mg<br />

Kg por via oral ó 370 mg/Kg<br />

EV.<br />

<br />

<br />

Toxicidad Cronica:<br />

Ligada a <strong>la</strong> hiperp<strong>la</strong>sia <strong>de</strong> celu<strong>la</strong>s parietales.<br />

Con altas dosis se observo incremento <strong>de</strong>l peso gas-<br />

trico y hepatico en perros y ratas,reversible con <strong>la</strong><br />

supresion <strong>de</strong>l IBP.<br />

Hipertrofia tiroi<strong>de</strong>a y reduccion <strong>de</strong> <strong>la</strong> <strong>de</strong>gradacion<br />

<strong>de</strong>l Colesterol (Reversible)

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