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Concepto de enfermedad inflamatoria articular en el adulto

Concepto de enfermedad inflamatoria articular en el adulto

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Sinovial: blanco<br />

<strong>de</strong> la inflamación<br />

En la AR<br />

Hiperplasia sinovial<br />

Agregados linfoi<strong>de</strong>os<br />

Angiogénesis<br />

Plasma<br />

c<strong>el</strong>l<br />

RF<br />

IL-4<br />

IL-6<br />

IL-10<br />

IL-4<br />

IL-10<br />

Th0<br />

Th2<br />

Macrophage<br />

Plasma<br />

c<strong>el</strong>l<br />

RF<br />

IL-4<br />

IL-6<br />

IL-10<br />

IL-4<br />

IL-10<br />

Th0<br />

Th2<br />

Macrophage<br />

IFN-γ<br />

IL-12<br />

Interferon-γ<br />

Synovium<br />

IFN-γ<br />

Interferon-γ<br />

IL-12<br />

B c<strong>el</strong>l<br />

CD4 + T c<strong>el</strong>l<br />

OPGL<br />

CD11<br />

Chondrocyte<br />

Osteoclast<br />

Fibroblast<br />

Production of metalloproteinases and<br />

other effector molecules<br />

TNF-α<br />

IL-1<br />

IL-6<br />

Synovium<br />

B c<strong>el</strong>l<br />

OPGL<br />

CD69<br />

CD4 + T c<strong>el</strong>l CD11<br />

CD69<br />

CD11<br />

TNF-α<br />

IL-1<br />

IL-6<br />

Migration of polymorphonuclear c<strong>el</strong>ls<br />

Erosion of bone and cartilage<br />

Osteoclast<br />

Fibroblast<br />

Chondrocyte<br />

Production of metalloproteinases and<br />

other effector molecules<br />

Migration of polymorphonuclear c<strong>el</strong>ls<br />

Erosion of bone and cartilage

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