Antibiotics for sore throat. Cochrane.Database.Syst.Rev. - sepeap
Antibiotics for sore throat. Cochrane.Database.Syst.Rev. - sepeap
Antibiotics for sore throat. Cochrane.Database.Syst.Rev. - sepeap
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Antibióticos para la faringitis<br />
Characteristics of included studies<br />
Participants<br />
Interventions<br />
Outcomes<br />
Notes<br />
Allocation concealment<br />
Study<br />
Methods<br />
Participants<br />
Interventions<br />
Outcomes<br />
Notes<br />
Allocation concealment<br />
Study<br />
Methods<br />
Participants<br />
Interventions<br />
Outcomes<br />
Notes<br />
Allocation concealment<br />
Study<br />
Methods<br />
Participants<br />
Interventions<br />
One hundred and seventy-eight patients aged 4 to 29 years with streptococcal<br />
pharyngitis. Patients had symptom duration of less than 4 days. Results reported <strong>for</strong><br />
57 patients with severe illness only<br />
Eight individual doses of penicillin or unmedicated placebo<br />
Symptoms of <strong>sore</strong> <strong>throat</strong> and fever<br />
Phone report after 48 hours used to measure outcome at day 3<br />
D – Not used<br />
Nelson 1984<br />
Subject randomised to conditions by hospital number allocation. An oral placebo was<br />
used to single blind patients, however outcome was not determined blind<br />
51 children aged 5 to 11 years. Sixteen subjects were excluded because they did not<br />
produce Group A Beta Haemolytic Streptococcus positive <strong>throat</strong> swabs, leaving 35<br />
subjects. Children with history of penicillin hypersensitivity were also excluded<br />
Intramuscular penicillin or oral syrup placebo as a control group<br />
Symptoms of <strong>sore</strong> <strong>throat</strong> and fever<br />
No antipyretics were administered<br />
C – Inadequate<br />
Petersen 1997<br />
Randomised placebo-controlled trial of patients' culture negative to Group A<br />
Streptococcus<br />
One hundred and eighty-six adults (aged 18 to 50) presenting to an ambulatory setting,<br />
whose chief complaint was <strong>sore</strong> <strong>throat</strong>, and whose GAS culture was subsequently<br />
found to be negative<br />
Treatment of either erythromycin (333 mg, 3 times daily), or placebo<br />
Main outcomes - time to improvement in <strong>sore</strong> <strong>throat</strong>, cough, activity level, and sense<br />
of well being. Patients completed a daily questionnaire on the progress of outcome<br />
measures. Follow up visits were arranged 2 to 3 weeks after enrolment <strong>for</strong> repeat<br />
cultures, collect diaries and assess compliance<br />
It is not clear how many patients kept diaries <strong>for</strong> the <strong>sore</strong> <strong>throat</strong> data in each group.<br />
Authors excluded GAS positive patients, (15 out of 212 initially randomised). Authors<br />
are being contacted <strong>for</strong> raw data<br />
A – Adequate<br />
Pichichero 1987<br />
Double blind placebo trial, randomised by a table of random numbers<br />
One hundred and fourteen Group A Beta Haemolytic Streptococcus positive children<br />
aged 4 to 18 years. Children were excluded from the study if: a <strong>throat</strong> swab was negative<br />
<strong>for</strong> Group A Beta Haemolytic Streptococcus; were allergic to penicillin; had received<br />
penicillin in past 7 days; had another acute illness within seven days, had a Group A<br />
Beta Haemolytic Streptococcus positive swab in past month, or had another concurrent<br />
infection that required antibiotics<br />
Oral penicillin <strong>for</strong> <strong>for</strong>ty eight hours or an identical looking and tasting oral placebo used<br />
<strong>for</strong> the control condition<br />
Página 17<br />
Copyright © John Wiley & Sons Ltd. Usado con permiso de John Wiley & Sons, Ltd.