PDF NÃºmero - NefrologÃa

More documents

Recommendations

Info

Carlos Jiménez et al. Darbepoetina alfa tras el trasplante renal originales Nephrol Dial Transplant 2009;24(3):1015-23. 24. Macdougall IC. The role of ACE inhibitors and angiotensin II receptor blockers in the response to epoetin. Nephrol Dial Transplant 1999;14(8):1836-41. 25. López Oliva MO, Del Castillo Caba D, Fernández Fresnedo G. Manejo de la anemia en la enfermedad renal cronica del paciente trasplantado renal. Nefrologia 2009;29 Suppl 1:25-30. 26. Breggia AC, Wojchowski DM, Himmelfarb J. JAK2/Y343/STAT5 signaling axis is required for erythropoietin-mediated protection against ischemic injury in primary renal tubular epithelial cells. Am J Physiol Renal Physiol 2008;295(6):F1689-95. 27. Fernández Fresnedo G, Palomar R, Rodrigo E, Ruiz JC, de Francisco AL, Cotorruelo JG, et al. Prevalence of anemia in renal transplant patients: results from MOST, an observational trial. Transplant Proc 2005;37(9):3821-2. 28. Pfeffer MA, Burdmann EA, Chen CY, Cooper ME, de Zeeuw D, Eckardt KU, et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 2009;361(21):2019- 32. 29. Molnar MZ, Czira M, Ambrus C, Szeifert L, Szentkiralyi A, Beko G, et al. Anemia is associated with mortality in kidney-transplanted patients—a prospective cohort study. Am J Transplant 2007;7(4):818- 24. 30. Winkelmayer WC, Chandraker A, Alan Brookhart M, Kramar R, Sunder-Plassmann G. A prospective study of anaemia and long-term outcomes in kidney transplant recipients. Nephrol Dial Transplant 2006;21(12):3559-66. 31. Chhabra D, Grafals M, Skaro AI, Parker M, Gallon L. Impact of anemia after renal transplantation on patient and graft survival and on rate of acute rejection. Clin J Am Soc Nephrol 2008;3(4):1168-74. 32. Kamar N, Rostaing L. Negative impact of one-year anemia on longterm patient and graft survival in kidney transplant patients receiving calcineurin inhibitors and mycophenolate mofetil. Transplantation 2008;85(8):1120-4. Enviado a Revisar: 10 Abr. 2012 | Aceptado el: 24 Oct. 2012 Nefrologia 2013;33(1):107-15 115
originales http://www.revistanefrologia.com © 2013 Revista Nefrología. Órgano Oficial de la Sociedad Española de Nefrología Protective effect of alpha tocopherol on contrast-induced nephropathy in rats Supranee Kongkham 1 , Siriwan Sriwong 2 , Adis Tasanarong 3 1 Department of Preclinical Sciences. Faculty of Medicine. Thammasat University. Khlong Luang, Pathumthani (Thailand) 2 Reserch Office. Faculty of Medicine. Thammasat University. Khlong Luang, Pathumthani (Thailand) 3 Nephrology Unit. Department of Medicine. Faculty of Medicine.Thammasat University. Khlong Luang, Pathumthani (Thailand) Nefrologia 2013;33(1):116-23 doi:10.3265/Nefrologia.pre2012.Nov.11736 ABSTRACT Background: Contrast-induced nephropathy (CIN) is a prominent cause of in-hospital acute kidney injury occurring after the administration of intravenous radiocontrast medium. Oxidative stress has been proposed as one of the more important mechanisms in the pathogenesis of CIN. The aim of the present study has been to determine the effect of alpha tocopherol on the reduction of renal damage in a rat model of CIN. Methods: Male Sprague Dawley rats were subjected into six groups pretreated with alpha-tocopherol (250 or 500mg/kg/day) or the vehicle tweeen80 for 5 days before the induction of CIN. Renal function and oxidative stress markers; level of malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD) activity were determined. Kidney tissues were sectioned for pathohistological examination. Results: In the contrast media (CM) group, an increase in serum urea and creatinine was found. Tubular necrosis and peritubular capillary congestion were demonstrated in this group. Also, an imbalance of oxidative stress markers; an increase in MDA and a decreased SOD activity in kidney were shown. On the contrary, in CIN-induced rats administrated with alpha-tocopherol group, a significant reduction of renal function and renal MDA, together with a significant increase of renal SOD, were observed. Interestingly, a reduction in MDA and an increase of TAC in serum, along with prevention of tubular injury, were demonstrated in this group, as compared to the CM group. Conclusion: This present study demonstrated that alpha tocopherol showed protective effect on the rat renal damage induced CIN. Therefore, this vitamin could be used as an antioxidant to attenuate the radiocontrast oxidative damage. Keywords: Contrast-induced nephrophathy (CIN). Oxidative stress. Alpha tocopherol. Correspondence: Adis Tasanarong Faculty of Medicine. Thammasat University. 12121, Khlong Luang, Pathumthani, Thailand, adis_tasanarong@hotmail.com Efecto protector del alfa-tocoferol en nefropatía inducida por contraste en ratas RESUMEN Antecedentes: La nefropatía inducida por contraste (NIC) constituye una causa importante del fracaso renal agudo en pacientes hospitalizados. Esta tiene lugar tras la administración de un medio de radiocontraste intravenoso. El estrés oxidativo se ha presentado como uno de los mecanismos más importantes de la patogénesis de la NIC. El objetivo de este estudio es determinar el efecto del alfa-tocoferol sobre la reducción del fracaso renal en un modelo de rata de NIC. Métodos: Las ratas Sprague Dawley machos, tratadas previamente con alfa-tocoferol (250 o 500 mg/kg/día) o con tween80 durante los 5 días anteriores a la inducción de CIN, fueron divididas en 6 grupos. Se determinaron los marcadores de la función renal y del estrés oxidativo, el nivel de malondialdehído (MDA), la capacidad antioxidante total (CAT) y la actividad de la superóxido dismutasa (SOD). Se seccionaron los tejidos de los riñones para el examen histopatológico. Resultados: En el grupo de medio de contraste (MC), se detectó un aumento de la urea sérica y de la creatinina. Asimismo, se demostró la presencia de necrosis tubular y de congestión capilar peritubular en este grupo. También se detectó un desequilibrio de los marcadores de estrés oxidativo, un aumento de MDA y una disminución de la actividad de la SOD en el riñón. Por el contrario, en el grupo de ratas con NIC inducida a las que se les administró alfa-tocoferol, se observó una reducción importante de la función renal y de la MDA renal, junto con un aumento significativo de la SOD renal. Curiosamente, en comparación con el grupo MC, en este grupo se demostró una reducción de MDA y un aumento de la CAT sérica, así como la prevención de la lesión tubular. Conclusión: Este estudio ha demostrado que el alfa-tocoferol posee un efecto protector del daño renal en ratas con NIC inducida. Por lo tanto, esta vitamina podría utilizarse como antioxidante para atenuar el daño oxidativo del radiocontraste. Palabras clave: Nefropatía inducida por contraste. Estrés oxidativo. Alfa-tocoferol. INTRODUCTION Contrast-induced nephropathy (CIN) remains the third most common cause of hospital-acquired acute renal failure, fol- 116
Page 1 and 2:
Incluida en ISI-WOK, MEDLINE, EMBAS
Page 3 and 4:
Sociedad http://www.revistanefrolog
Page 5 and 6:
sumario Incluida en ISI-WOK, MEDLIN
Page 7 and 8:
contents Included in ISI-WOK, MEDLI
Page 9 and 10:
comentario editorial Elvira Fernán
Page 11 and 12:
Page 13 and 14:
Page 15 and 16:
evisiones cortas Julia Fijo-López-
Page 17 and 18:
Page 19 and 20:
Page 21 and 22:
evisiones cortas http://www.revista
Page 23 and 24:
evisiones cortas Francesc Moreso et
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
Page 35 and 36:
artículo especial Josep M. Campist
Page 37 and 38:
Page 39 and 40:
Page 41 and 42:
Page 43 and 44:
Page 45 and 46:
Page 47 and 48:
Page 49 and 50:
Page 51 and 52:
Page 53 and 54:
originales http://www.revistanefrol
Page 55 and 56:
originales José L. Górriz et al.
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
originales Cristina Aparicio-López
Page 71 and 72: originales Cristina Aparicio-López
Page 77 and 78: originales http://www.revistanefrol
Page 79 and 80: originales J. Emilio Sánchez-Álva
Page 85 and 86: originales Celestino Piñera-Haces
Page 93 and 94: originales Rafael Sánchez-Villanue
Page 101 and 102: originales Isidro Torregrosa-Maicas
Page 107 and 108: originales Marco U. Martínez-Mart
Page 115 and 116: originales Carlos Jiménez et al. D
Page 121: originales Carlos Jiménez et al. D
Page 125 and 126: originales Supranee Kongkham et al.
Page 131 and 132: original breve http://www.revistane
Page 133 and 134: original breve Noemí Esparza-Mart
Page 135 and 136: caso clínico http://www.revistanef
Page 137 and 138: caso clínico Eva Márquez et al. C
Page 139 and 140: caso clínico Eva Márquez et al. C
Page 141 and 142: cartas al director http://www.revis
Page 143 and 144: cartas al director Figure 2. PAS st
Page 145 and 146: cartas al director Datos demográfi
Page 147 and 148: cartas al director sicos (máquinas
Page 149 and 150: cartas al director los años (11,8
Page 151 and 152: cartas al director En la población
Page 153 and 154: cartas al director chronic renal fa
Page 155 and 156: cartas al director Two renal biopsi
Page 157 and 158: cartas al director trasplante renal
Page 159 and 160: cartas al director Dear Editor, De
Page 161: cartas al director 7. Robson M, Cô
show all

PDF NÃºmero - NefrologÃ­a

Create successful ePaper yourself

Delete template?

Save as template?

PDF NÃºmero - NefrologÃa