SMQ-V043 N-001_ligas_size.pdf - Journal of the Mexican Chemical ...
SMQ-V043 N-001_ligas_size.pdf - Journal of the Mexican Chemical ...
SMQ-V043 N-001_ligas_size.pdf - Journal of the Mexican Chemical ...
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State-<strong>of</strong>-<strong>the</strong>-art Protein Structural Biology 29<br />
11. We are at <strong>the</strong> present time initiated an ongoing research<br />
project to obtain <strong>the</strong> DNA sequence <strong>of</strong> <strong>the</strong> genomic DNA<br />
from blood samples <strong>of</strong> patients afflicted with Amelogenesis<br />
imperfecta in Mexico and subsequently clone <strong>the</strong> defective<br />
protein for structural biological research.<br />
Acknowledgements<br />
VR expresses his indebtedness to Pr<strong>of</strong>. Melvin J. Glimcher,<br />
Harriet Peabody Pr<strong>of</strong>essor <strong>of</strong> Orthopaedic Surgery, Harvard<br />
Medical School, Harvard University, Boston, MA for initiating<br />
him into <strong>the</strong> field <strong>of</strong> biomineralization in early 80’s. Much<br />
<strong>of</strong> <strong>the</strong> research has been supported through research grants<br />
(RO1’s) from National Institutes <strong>of</strong> Health since 1985 to V. R,<br />
Harvard Medical School, Harvard University, Cambridge,<br />
MA, A Program Project Grant to <strong>the</strong> Laboratory for <strong>the</strong><br />
Skeletal Disorders and Rehabilitation, Dept. <strong>of</strong> Orthopaedic<br />
Research, Harvard Medical School, NIH, NSF, and Harvard<br />
University provided generous support for <strong>the</strong> purchase <strong>of</strong> 500<br />
and 600 MHz NMR spectrometers used in this study. The 750<br />
MHz NMR studies on recombinant mouse amelogenin were<br />
performed at <strong>the</strong> Battelle Northwest Laboratories, Richland,<br />
WA. Mr. Jose Trinidad Vivas Cortes, Institute <strong>of</strong> Chemistry,<br />
UNAM and Mr. Masahiro Tanikawa Ishiwara, Mexico City,<br />
Mexico rendered valuble help in <strong>the</strong> preparation <strong>of</strong> <strong>the</strong> art<br />
work which is sincerely acknowledged.<br />
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