to get the file - OCW CEU
to get the file - OCW CEU
to get the file - OCW CEU
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● Anilinas: clorambucilo (antineoplásico)<br />
CH 3OH, HCl<br />
esterificación<br />
(CH 2) 3CO 2CH 3<br />
O 2N<br />
HNO 3, H 2SO 4<br />
nitración<br />
e hidrólisis<br />
(CH 2) 3CO 2CH 3<br />
H 2O/<br />
O 2N<br />
1 H 2/Pd<br />
O<br />
2 HOCH2CH2 N<br />
(CH2) 3CO2CH3 HOCH2CH2 ClCH 2CH 2<br />
ClCH 2CH 2<br />
N<br />
(CH 2) 3CO 2CH 3<br />
H<br />
Hidrólisis<br />
H 2N<br />
ClCH 2CH 2<br />
ClCH 2CH 2<br />
(CH 2) 3CO 2H<br />
SOCl 2<br />
N<br />
Ar N<br />
Clorambucilo<br />
(CH 2) 3CO 2CH 3<br />
(CH 2) 3CO 2H<br />
99
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