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to get the file - OCW CEU

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Derivados de ácidos arilacéticos: amidas y ésteres<br />

- Amidas: Diisopiramida (antiarrítmico, bloqueo de los<br />

canales de sodio)<br />

1. NaNH 2<br />

CH2 CN NaNH2 o HNa<br />

2. Cl(CH 2) 2N(CH(CH 3) 2<br />

N<br />

C CONH 2<br />

(CH 2) 2N(CH(CH 3) 2<br />

CH<br />

Cl<br />

N<br />

CN C CN<br />

N<br />

C CN<br />

(CH 2) 2N(CH(CH 3) 2<br />

Diisopiramida<br />

H 2SO 4<br />

H<br />

N<br />

63

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