to get the file - OCW CEU
to get the file - OCW CEU
to get the file - OCW CEU
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Síntesis de ácidos arilacéticos -sustituidos<br />
i-Bu<br />
A) alquilación en de carbaniones estabilizados<br />
- Ibuprofeno: arilace<strong>to</strong>nitrilos<br />
- Naproxeno: arilaceta<strong>to</strong>s<br />
HCl<br />
CH 2O<br />
i-Bu CH2 CN i-Bu<br />
NaNH2 o HNa<br />
CH 3<br />
i-Bu C<br />
H<br />
CN<br />
i-Bu CH 2 Cl<br />
NaOH,H 2O<br />
HCl, H 2O<br />
KCN<br />
CH<br />
CN<br />
ICH 3<br />
i-Bu<br />
CH3 C<br />
H<br />
COOH<br />
Ibuprofeno<br />
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