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to get the file - OCW CEU

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Propoxifeno: análogo de la metadona (analgésico<br />

opiaceo)<br />

Ph<br />

O<br />

CH 3<br />

BrMgCH 2Ph<br />

Ph<br />

H 3O<br />

Ph<br />

H<br />

O<br />

O<br />

CH 3<br />

H<br />

O<br />

H HN(CH 3) 2 HCl<br />

1. reacción de Mannich<br />

2. resolución<br />

Ph<br />

Ph<br />

N(CH 3) 2<br />

H<br />

OH<br />

CH 3<br />

N(CH 3) 2<br />

(d)-propoxifeno<br />

Ph<br />

O<br />

H<br />

O<br />

CH 3<br />

O O<br />

N(CH 3) 2<br />

anhídrido propiónico<br />

(d)-propoxifeno:<br />

hipnoanalgésico<br />

(l)-propoxifeno:<br />

antitusígeno<br />

55

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