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Tau - Saber ULA

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SÍNTESIS DE Aβ<br />

1. β secretasa genera el terminal N de Aβ<br />

2. γ secretasa produce clivaje intramembrana<br />

y libera el Aβ<br />

Presenilin (PS) es la proteasa en γ secretasa<br />

Aβ 1-40 más abundante menos tóxico<br />

Aβ 1-42 en Alzheimer es más abundante<br />

y se agrega fácil<br />

En Alzheimer familiar: Aβ 1-42 está aumentado

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