Ferro, María Elena Figura 4: Nivel <strong>de</strong> IgG total y <strong>de</strong> subclases <strong>de</strong> IgG en lágrimas <strong>de</strong> niños <strong>de</strong> 3 a meses <strong>de</strong> edad normales y con dacrioestenosis asociada a conjuntivitis causada por cocos, bacilos o virus. (*: p
14 Adkins B. neonatal T cell function. J Pediatr Gactroenterol Nutr 2005; 40 (suppl 1): 5. 15 Marchant A, Goldman M. T cell-mediated immune responses in human newborns: ready to learn?. Clin Exp Immunol 2005; 141: 10. 16 Maródi L. Neonatal innate immunity to infectious agents. Infect Immun 2006; 74: 1999. 17 Fa<strong>de</strong>n HS. Dacryocystitis in children. Clinical Pediatrics 2006; 45: 567. 18 Kuchar A, Lucas J, Steinkogler FJ. Bacteriology and antibiotic therapy in congenital nasolacrimal duct obstruction. Acta Ophthalmol Scand 2000; 78: 694. 19 Di Bartolomeo S, Higa M, Janer M, Pennisi A, Balbin G, Priore G. Conjuntivitis neonatal en un hospital <strong>de</strong>l Gran Buenos Aires. Situación <strong>de</strong> los últimos 5 años. Rev Argent Microbiol 2005; 37: 139. 20 Usha K, Smitha S, Shah N, Lalitha P, Kelkar R. Spectrum and the susceptibilities of microbial isolates in cases of congenital nasolacrimal duct obstruction. J AAPOS2006; 10: 469. 21 Karlsson H, Hessle C, Rudin A. Innate immune responses of human neonatal cells to bacteria from the normal gastrointestinal flora. Infect Immun 2002; 70: 6688. 22 Li L, Lee HH, Bell JJ, Greg RK, Ellis JS, Gessner A, Zaghouani H. IL-4 utilizes an alternative receptor to drive apoptosis of Th1 cells and skews neonatal immunity toward Th2. Immunity 2004: 20: 429 23 Rose S, Lichtenheld M, Foote MR, Adkins B. Murine neonatal CD4+ cells are poised for rapid Th2 effector-like function. J Immunol 2007; 178: 2667. 24 Thorarinsdottir HK, Ludviksson BR, Vikingsdottir T, LeopoldsdottirMO, Ardal B,Jonsson T, Valdimarsson H, Arason GH. Childhood levels of immunoglobulins and mannano-binding lectin in relation to infections and allergy. Scand J Immunol 2005; 61: 466. 25 Corthésy B. Roundtrip ticket for secretory IgA: Role in mucosal homeostasis? J Immunol 2007: 178: 27. 26 Stahl J, Barney N. Ocular allergic disease. Curr Opin Allergy Clin Immunol 2004: 4: 455 Primera infancia y dacrioestenosis congénita: marcada <strong>de</strong>sviación hacia respuesta no protectiva Th2 frente a ciertas infecciones conjuntivales 27 Stumpf TH, Case R, Shimeld C, Easty DL, Hill TJ. Primary herpes simplex virus type 1 infection of the eye triggers similar immune responses in the cornea and the skin of the eyelids. J Gen Virol 2002; 83: 15<strong>79</strong>. 28 Noverr MC, Huffnagle GB. The ´microflora hypothesis´ of allergic disease. Clin Exp Allergy 2005: 35: 1511. 29 Lun<strong>de</strong>ll AC, An<strong>de</strong>rson K, Josefsson E, Steinkasserer A, Rudin A. Soluble CD14 and CD83 from human neonatal antigen-presenting cells are inducible by commensal bacteria and suppress allergeninduced human neonatal Th2 differentiation. Infec Immun 2007; 75: 4097 30 Karlsson H, Larsson P, Wold AE, Rudin A. Pattern of cytokine responses to gram-positive and gram-negative commensal bacteria is profoundly changed when monocytes differentiate into <strong>de</strong>ndritic cells. 31 Proud D, Chow CW. Role of viral infections in asthma and chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2006; 35: 513 32 Horvat JC, Beagley KW, Wa<strong>de</strong> MA, Preston JA, Hansbro NG, Hickey DK, Kaiko GE, Gibson PG, Foster PS, Hansbro PM. Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease. Am J Respir Crit Care Med 2007; 176: 556. 33 Holt PG, Sly PD. Interactions between respiratory tract infections and atopy in the aetiology of asthma. Eur Respir J 2002; 19: 538 34 Nja E, Nystad W, Hetlevik O, Carlsen KCL,Carlsen KH. Airway infections in the infancy and the presence of allergy and asthma in school age children. Arch Dis Child 2003: 88: 566. 35 Nafstad P, Brunekreef B, Skrondal A, Nystad W. Early respiratory infections, asthma, and allergy: 10-year follow-up of the oslo birth cohort. Pediatricts 2005; 116: e255. 36 Björkstén B. Effects of intestinal microflora and the environment on the <strong>de</strong>velopment of asthma and allergy. Springer Semin Immunopathol 2004; 25: 257. [ 7 ]
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