TESIS FICOTOXINAS MARINAS EVA FONFRIA

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90 Bibliografía [69] Garthwaite, I., Ross, K. M., Miles, C. O., Briggs, L. R., Towers, N. R., Borrell, T. and Busby, P. (2001) Integrated enzyme-linked immunosorbent assay screening system for amnesic, neurotoxic, diarrhetic, and paralytic shellfish poisoning toxins found in New Zealand. J AOAC Int 84, 1643-1648. [70] Poli, M. A., Rein, K. S. and Baden, D. G. (1995) Radioimmunoassay for PbTx-2-type brevetoxins: epitope specificity of two anti-PbTx sera. J AOAC Int 78, 538-542. [71] Hua, Y., Lu, W., Henry, M. S., Pierce, R. H. and Cole, R. B. (1995) On-line high-performance liquid chromatography-electrospray ionization mass spectrometry for the determination of brevetoxins in "red tide" algae. Anal Chem 67, 1815-1823. [72] Twiner, M. J., Bottein Dechraoui, M. Y., Wang, Z., Mikulski, C. M., Henry, M. S., Pierce, R. H. and Doucette, G. J. (2007) Extraction and analysis of lipophilic brevetoxins from the red tide dinoflagellate Karenia brevis. Anal Biochem 369, 128-135. [73] Shea, D. (1997) Analysis of brevetoxins by micellar electrokinetic capillary chromatography and laser-induced fluorescence detection. Electrophoresis 18, 277-283. [74] Kat, M. (1979) The ocurrence of Prorocentrum species and coincidental gastrointestinal illness of mussel consumers, In Toxic dinoflagellate blooms. (Taylor, D. and Selinger, H., Eds.) pp 215-220, Elsevier, Amsterdam. [75] Gestal-Otero, J. J. (2008) Epidemiologic impact of diarrheic toxins, In Seafood and freshwater toxins: pharmacology, physiology and detection. 2nd edition (Botana, L. M., Ed.) pp 53-75, CRC Press, New York. [76] McNabb, P. (2008) Chemistry, metabolism and chemical analysis of okadaic acid group toxins., In Seafood and freshwater toxins: pharmacology, physiology and detection. 2nd edition (Botana, L. M., Ed.) pp 209-228, CRC Press, Boca Raton. [77] Tachibana, K., Scheuer, P. J., Tsukitani, Y., Kikuchi, H., Engen, D. V., Clardy, J., Gopichand, Y. and Schmitz, F. J. (1981) Okadaic acid, a cytotoxic polyeher from two marine sponges of the genus Halicondria. J. Am. Chem. Soc. 103, 2469-2471.
91 Bibliografía [78] Lee, J. S., Igarashi, T., Fraga, S., Dahl, E., Hovgaard, P. and Yasumoto, T. (1989) Determination of diarrhetic shellfish toxins in various dinoflagellate species. Journal of Applied Phycology 1, 147-152. [79] Delgado, M., Garces, E. and Camp, J. (1996) Growth and behavior of Dinophysis sacculus from NW Mediterranean Sea, In Harmful and Toxic Algal Blooms. (Yasumoto, T., Oshima, Y. and Fukuyo, Y., Eds.), Intergovernamental Oceanographic Commission of UNESCO, Sendai, Japan. [80] Zhou, J. and Fritz, L. (1993) Ultrastrucutre of two toxic marine dinoflagellates, Prorocentrum lima and Prorocentrum maculosum. Phycologia 32, 444-450. [81] Morton, S. L. and Tindall, D. R. (1996) Determination of okadaic acid content of dinoflagellate cells: a comparison of the HPLC-fluorescent method and two monoclonal antibody ELISA test kits. Toxicon 34, 947-954. [82] Morton, S. L., Moeller, P. D., Young, K. A. and Lanoue, B. (1998) Okadaic acid production from the marine dinoflagellate Prorocentrum belizeanum Faust isolated from the Belizean coral reef ecosystem. Toxicon 36, 201-206. [83] Dickey, R. W., Bobzin, S. C., Faulkner, D. J., Bencsath, F. A. and Andrzejewski, D. (1990) Identification of okadaic acid from a Caribbean dinoflagellate, Prorocentrum concavum. Toxicon 28, 371-377. [84] Morton, S. L. (1998) Morphology and toxicology of Prorocentrum faustiae sp. nov., a toxic species of non-planktonic dinoflagellate from Heron Island, Australia. Bot. Mar. 41, 565-569. [85] Ten-Hage, L., Delaunay, N., Pichon, V., Coute, A., Puiseux-Dao, S. and Turquet, J. (2000) Okadaic acid production from the marine benthic dinoflagellate Prorocentrum arenarium Faust (Dinophyceae) isolated from Europa Island coral reef ecosystem (SW Indian Ocean). Toxicon 38, 1043- 1054. [86] Aune, T. and Yndstad, M. (1993) Diarrhetic shellfish poisoning, In Algal toxins in seafood and drinking water. (Falconer, I. R., Ed.) pp 87-104, Academic Press, London. [87] Bialojan, C. and Takai, A. (1988) Inhibitory effect of a marine sponge toxin, okadaic acid, on protein phosphatases. Biochem. J. 256, 283-290.
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UNIVERSIDAD DE SANTIAGO DE COMPOSTE
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Natalia Vilariño del Río, investi
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AGRADECIMIENTOS Quisiera agradecer
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ABREVIATURAS ADN Ácido desoxirribo
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ÍNDICE
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INTRODUCCIÓN
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2 Introducción ratón. Este métod
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Carbamadas Sulfocarmadas Decarbamad
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Figura 2. Estructura química gener
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Figura 3. Estructura química del
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Figura 4. Estructura química de la
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12 Introducción Gymnodinium sellif
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14 Introducción Existe la hipótes
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Espiro-prorocentrimina 16 Introducc
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18 Introducción dos espines de amb
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Aplicaciones 20 Introducción Los e
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22 Introducción Por encima de un c
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24 Introducción Figura 15. Detecci
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26 Introducción En el campo de la
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28 Introducción y los 100 nl. La I
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2. OBJETIVOS 29 Objetivos Las ficot
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3. PUBLICACIONES 31 Publicaciones E
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33 Publicaciones bungarotoxina marc
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35 Publicaciones
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37 Publicaciones
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39 Publicaciones
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41 Publicaciones
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43 Publicaciones
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Artículo 2. Feasibility of using a
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46 Publicaciones
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48 Publicaciones
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50 Publicaciones
Page 79 and 80: 51 Publicaciones
Page 87: Artículo 4. Feasibility of gymnodi
Page 90 and 91: Abstract 60 Publicaciones The detec
Page 92 and 93: 62 Publicaciones problems derived f
Page 94 and 95: 64 Publicaciones added to 40 µl of
Page 96 and 97: 66 Publicaciones range was between
Page 98 and 99: 68 Publicaciones The IC50 values ob
Page 100 and 101: 70 Publicaciones [5] E. Takahashi,
Page 102 and 103: 72 Publicaciones Figure 2. 13-desme
Page 104 and 105: 13-desmethyl C spirolide (nM) Gymno
Page 109 and 110: 4. DISCUSIÓN GENERAL 77 Discusión
Page 111 and 112: 79 Discusión general cruzada con l
Page 113: CONCLUSIONES
Page 119: BIBLIOGRAFÍA
Page 122 and 123: 84 Bibliografía amending Regulatio
Page 124 and 125: 86 Bibliografía [28] Llewellyn, L.
Page 126 and 127: 88 Bibliografía [50] Khan, D., Ahm
Page 130 and 131: 92 Bibliografía [88] Takai, A., Mu
Page 132 and 133: 94 Bibliografía [108] Leira, F., A
Page 134 and 135: 96 Bibliografía [128] Kharrat, R.,
Page 136 and 137: 98 Bibliografía [146] Takada, N.,
Page 138 and 139: 100 Bibliografía [169] Nasir, M. S
Page 140: RESUMEN Las ficotoxinas marinas son
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TESIS FICOTOXINAS MARINAS EVA FONFRIA

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