TESIS FICOTOXINAS MARINAS EVA FONFRIA

More documents

Recommendations

Info

88 Bibliografía [50] Khan, D., Ahmed, M. S., Arakawa, O. and Onoue, Y. (1995) Properties of neurotoxins separated from a harmful red tide organism Chattonella marina. Isr. J. Aquac. 47, 137-141. [51] Khan, D., Ahmed, M. S., Arakawa, O. and Onoue, Y. (1996) A toxicological study of the marine phytoflagellate, Chatonella antiqua (Raphidophyceae). Phycologia 35, 239-244. [52] Khan, D., Arakawa, O. and Onoue, Y. (1996) Neurotoxin production by a chloromonad Fibrocapsa japonica (Raphydophyceae). Journal of the World Aquaculture Society 27, 254-263. [53] Khan, D., Arakawa, O. and Onoue, Y. (1997) Neurotoxins in a toxic red tide of Heterosigma akashiwo (Raphidophyceae) in Kagoshima Bay, Japan. Aquaculture Research 28, 9-14. [54] Magaña, H. A., Contreras, C. and Villareal, T. A. (2003) A historical assessment of Karenia brevis in the western Gulf of Mexico. Harmful Algae 2, 163-171. [55] Nozawa, A., Tsuji, K. and Ishida, H. (2003) Implication of brevetoxin B1 and PbTx-3 in neurotoxic shellfish poisoning in New Zealand by isolation and quantitative determination with liquid chromatography-tandem mass spectrometry. Toxicon 42, 91-103. [56] Ishida, H., Muramatsu, N., Nukaya, H., Kosuge, T. and Tsuji, K. (1996) Study on neurotoxic shellfish poisoning involving the oyster, Crassostrea gigas, in New Zealand. Toxicon 34, 1050-1053. [57] Poli, M. A., Mende, T. J. and Baden, D. G. (1986) Brevetoxins, unique activators of voltage-sensitive sodium channels, bind to specific sites in rat brain synaptosomes. Mol Pharmacol 30, 129-135. [58] Trainer, V. L., Thomsen, W. J., Catterall, W. A. and Baden, D. G. (1991) Photoaffinity labeling of the brevetoxin receptor on sodium channels in rat brain synaptosomes. Mol Pharmacol 40, 988-994. [59] FAO/WHOI/IOC. (2004) Report of the Joint FAO/IOC/WHO ad hoc Expert Consultation on Biotoxins in Bivalve Molluscs. Available: http//www.fao.org/ag/agn/food/risk_biotoxin_en.stm, Oslo, Norway. [60] Flewelling, L. J., Naar, J. P., Abbott, J. P., Baden, D. G., Barros, N. B., Bossart, G. D., Bottein, M. Y., Hammond, D. G., Haubold, E. M., Heil, C. A., Henry, M. S., Jacocks, H. M., Leighfield, T. A., Pierce, R. H., Pitchford, T.
89 Bibliografía D., Rommel, S. A., Scott, P. S., Steidinger, K. A., Truby, E. W., Van Dolah, F. M. and Landsberg, J. H. (2005) Brevetoxicosis: red tides and marine mammal mortalities. Nature 435, 755-756. [61] Kreuder, C., Mazet, J. A., Bossart, G. D., Carpenter, T. E., Holyoak, M., Elie, M. S. and Wright, S. D. (2002) Clinicopathologic features of suspected brevetoxicosis in double-crested cormorants (Phalacrocorax auritus) along the Florida Gulf Coast. J Zoo Wildl Med 33, 8-15. [62] Bossart, G. D., Baden, D. G., Ewing, R. Y., Roberts, B. and Wright, S. d. (1998) Brevetoxicosis in manatees (Trichechus manatus latirostris) from the 1996 epizootic: gross, histologic, and immunohistochemical features. Toxicol. Pathol. 26, 276-282. [63] Aune, T. (2008) Risk assessment of marine toxins, In Seafood and freshwater toxins: pharmacology, physiology and detection. 2nd edition (Botana, L. M., Ed.) pp 3-20, CRC Press, Boca Raton. [64] APHA. (1985) Method for Ptychodiscus brevis toxins., In Laboratory procedures for the examination of seawater and shellfish, 5th edition pp 64- 80, American Public Health Association, Washington, D. C. [65] Watkins, S. M., Reich, A., Fleming, L. E. and Hammond, R. (2008) Neurotoxic shellfish poisoning. Mar Drugs 6, 431-455. [66] Dickey, R., Jester, E., Granade, R., Mowdy, D., Moncreiff, C., Rebarchik, D., Robl, M., Musser, S. and Poli, M. (1999) Monitoring brevetoxins during a Gymnodinium breve red tide: comparison of sodium channel specific cytotoxicity assay and mouse bioassay for determination of neurotoxic shellfish toxins in shellfish extracts. Nat Toxins 7, 157-165. [67] Rodriguez-Velasco, M. L. (2008) Toxin monitoring programs and regulatory view, In Seafood and freshwater toxins: pharmacology, physiology and detection. 2nd edition (Botana, L. M., Ed.) pp 919-932, CRC Press, Boca Raton. [68] Naar, J., Bourdelais, A., Tomas, C., Kubanek, J., Whitney, P. L., Flewelling, L., Steidinger, K., Lancaster, J. and Baden, D. G. (2002) A competitive ELISA to detect brevetoxins from Karenia brevis (formerly Gymnodinium breve) in seawater, shellfish, and mammalian body fluid. Environ Health Perspect 110, 179-185.
Page 1:
UNIVERSIDAD DE SANTIAGO DE COMPOSTE
Page 4 and 5:
Natalia Vilariño del Río, investi
Page 7:
AGRADECIMIENTOS Quisiera agradecer
Page 11 and 12:
ABREVIATURAS ADN Ácido desoxirribo
Page 13 and 14:
ÍNDICE
Page 16:
INTRODUCCIÓN
Page 20 and 21:
2 Introducción ratón. Este métod
Page 22 and 23:
Carbamadas Sulfocarmadas Decarbamad
Page 24 and 25:
Figura 2. Estructura química gener
Page 26 and 27:
Figura 3. Estructura química del
Page 28 and 29:
Figura 4. Estructura química de la
Page 30 and 31:
12 Introducción Gymnodinium sellif
Page 32 and 33:
14 Introducción Existe la hipótes
Page 34 and 35:
Espiro-prorocentrimina 16 Introducc
Page 36 and 37:
18 Introducción dos espines de amb
Page 38 and 39:
Aplicaciones 20 Introducción Los e
Page 40 and 41:
22 Introducción Por encima de un c
Page 42 and 43:
24 Introducción Figura 15. Detecci
Page 44 and 45:
26 Introducción En el campo de la
Page 46 and 47:
28 Introducción y los 100 nl. La I
Page 49:
2. OBJETIVOS 29 Objetivos Las ficot
Page 53 and 54:
3. PUBLICACIONES 31 Publicaciones E
Page 55:
33 Publicaciones bungarotoxina marc
Page 59 and 60:
35 Publicaciones
Page 61 and 62:
37 Publicaciones
Page 63 and 64:
39 Publicaciones
Page 65 and 66:
41 Publicaciones
Page 67 and 68:
43 Publicaciones
Page 69:
Artículo 2. Feasibility of using a
Page 72 and 73:
46 Publicaciones
Page 74 and 75:
48 Publicaciones
Page 76 and 77: 50 Publicaciones
Page 87: Artículo 4. Feasibility of gymnodi
Page 90 and 91: Abstract 60 Publicaciones The detec
Page 92 and 93: 62 Publicaciones problems derived f
Page 94 and 95: 64 Publicaciones added to 40 µl of
Page 96 and 97: 66 Publicaciones range was between
Page 98 and 99: 68 Publicaciones The IC50 values ob
Page 100 and 101: 70 Publicaciones [5] E. Takahashi,
Page 102 and 103: 72 Publicaciones Figure 2. 13-desme
Page 104 and 105: 13-desmethyl C spirolide (nM) Gymno
Page 109 and 110: 4. DISCUSIÓN GENERAL 77 Discusión
Page 111 and 112: 79 Discusión general cruzada con l
Page 113: CONCLUSIONES
Page 119: BIBLIOGRAFÍA
Page 122 and 123: 84 Bibliografía amending Regulatio
Page 124 and 125: 86 Bibliografía [28] Llewellyn, L.
Page 128 and 129: 90 Bibliografía [69] Garthwaite, I
Page 130 and 131: 92 Bibliografía [88] Takai, A., Mu
Page 132 and 133: 94 Bibliografía [108] Leira, F., A
Page 134 and 135: 96 Bibliografía [128] Kharrat, R.,
Page 136 and 137: 98 Bibliografía [146] Takada, N.,
Page 138 and 139: 100 Bibliografía [169] Nasir, M. S
Page 140: RESUMEN Las ficotoxinas marinas son
show all

TESIS FICOTOXINAS MARINAS EVA FONFRIA

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?