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Dr Gnant - ESMO Oral Presentation 08

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Study Endpoints (TAM vs ANA; ZOL vs No ZOL)<br />

• Primary endpoint<br />

– Disease-free survival (DFS)<br />

– DFS events: local recurrence, contralateral breast cancer,<br />

distant metastasis, secondary carcinoma, death<br />

• Secondary endpoints<br />

– Recurrence-free survival (RFS): local recurrence,<br />

contralateral breast cancer, distant metastasis,<br />

secondary carcinoma<br />

– Overall survival<br />

– Safety<br />

• Exploratory endpoint<br />

– Bone-metastases–free survival<br />

6

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