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Dr Gnant - ESMO Oral Presentation 08

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Incidence of Bone Metastases Was Reduced<br />

in Patients Receiving ZOL<br />

BMF survival, %<br />

100<br />

99<br />

98<br />

97<br />

96<br />

95<br />

94<br />

93<br />

92<br />

Hazard ratio (95% CI)<br />

Events, n vs No ZOL P value<br />

ZOL 16 0.676 (0.359, 1.272) .224<br />

No ZOL 24<br />

0 12 24 36 48 60 72 84<br />

Time since randomization, months<br />

Median follow-up = 48 months.<br />

BMF = Bone metastases-free; CI = Confidence interval; ZOL = Zoledronic acid.<br />

13

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