world cancer report - iarc
world cancer report - iarc
world cancer report - iarc
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worthy is the development of caspase<br />
inhibitors for the treatment of certain<br />
degenerative (non-<strong>cancer</strong>ous) diseases<br />
characterized by excess apoptosis.<br />
Drugs shown to induce apoptosis specifically<br />
include chemopreventive agents<br />
(Chemoprevention, p151), exemplified by<br />
REFERENCES<br />
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2. Kaufmann SH, Gores GJ (2000) Apoptosis in <strong>cancer</strong>:<br />
cause and cure. Bioessays, 22: 1007-1017.<br />
3. Parton M, Dowsett M, Smith I (2001) Studies of apoptosis<br />
in breast <strong>cancer</strong>. BMJ, 322: 1528-1532.<br />
4. Choisy-Rossi C, Yonish-Rouach E (1998) Apoptosis and<br />
the cell cycle: the p53 connection. Cell Death Differ, 5:<br />
129-131.<br />
5. Rich T, Allen RL, Wyllie AH (2000) Defying death after<br />
DNA damage. Nature, 407: 777-783.<br />
6. Peter ME, Krammer PH (1998) Mechanisms of CD95<br />
(APO-1/Fas)-mediated apoptosis. Curr Opin Immunol, 10:<br />
545-551.<br />
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in the analysis of mammalian apoptosis and TNF<br />
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302.<br />
8. Griffith TS, Lynch DH (1998) TRAIL: a molecule with<br />
multiple receptors and control mechanisms. Curr Opin<br />
Immunol, 10: 559-563.<br />
9. Gross A, McDonnell JM, Korsmeyer SJ (1999) BCL-2<br />
family members and the mitochondria in apoptosis. Genes<br />
Dev, 13: 1899-1911.<br />
10. Matsuyama S, Llopis J, Deveraux QL, Tsien RY, Reed<br />
JC (2000) Changes in intramitochondrial and cytosolic pH:<br />
118 Mechanisms of tumour development<br />
4-hydroxyphenylretinamide. Butyrate, a<br />
short-chain fatty acid produced by bacterial<br />
fermentation of dietary fibre, inhibits<br />
cell growth in vitro and promotes differentiation;<br />
it also induces apoptosis. Both<br />
roles may contribute to its prevention of<br />
colorectal <strong>cancer</strong>. Moreover, cyclo-oxyge-<br />
early events that modulate caspase activation during apoptosis.<br />
Nat Cell Biol, 2: 318-325.<br />
11. Chung HT, Pae HO, Choi BM, Billiar TR, Kim YM (2001)<br />
Nitric oxide as a bioregulator of apoptosis. Biochem<br />
Biophys Res Commun, 282: 1075-1079.<br />
12. Kumar S (1999) Regulation of caspase activation in<br />
apoptosis: implications in pathogenesis and treatment of<br />
disease. Clin Exp Pharmacol Physiol, 26: 295-303.<br />
13. Porter AG, Janicke RU (1999) Emerging roles of caspase-3<br />
in apoptosis. Cell Death Differ, 6: 99-104.<br />
14. Nicholson DW (2000) From bench to clinic with apoptosis-based<br />
therapeutic agents. Nature, 407: 810-816.<br />
15. Zhou BB, Elledge SJ (2000) The DNA damage<br />
response: putting checkpoints in perspective. Nature, 408:<br />
433-439.<br />
16. Brown JM, Wouters BG (1999) Apoptosis, p53, and<br />
tumor cell sensitivity to anti<strong>cancer</strong> agents. Cancer Res, 59:<br />
1391-1399.<br />
17. Zheng TS (2001) Death by design: the big debut of<br />
small molecules. Nat Cell Biol, 3: E43-E46.<br />
18. Altucci L, Rossin A, Raffelsberger W, Reitmair A,<br />
Chomienne C, Gronemeyer H (2001) Retinoic acid-induced<br />
apoptosis in leukemia cells is mediated by paracrine action<br />
of tumor-selective death ligand TRAIL. Nat Med, 7: 680-<br />
686.<br />
nase enzyme (COX-2) expression may<br />
modulate intestinal apoptosis via changes<br />
in Bcl-2 expression. Aspirin and similar<br />
drugs which inhibit COX-2 may promote<br />
apoptosis and prevent tumour formation.<br />
WEBSITE<br />
The European Cell Death Organization:<br />
http://www.ecdo.dote.hu/