Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX4-30
Reference, Study
Location, and
Period Study Description
United States
Hu et al. (1996)
Boston, MA
1991+
Kim et al. (1997)
Boston, MA
1991-95
Cheng et al. (1998)
Boston, MA
1991-95
Table AX4-8. Bone Lead Studies of Menopausal and Middle-aged to Elderly Subjects
Normative Aging Study.
Subjects were middle-aged and
elderly men who had community
(nonoccupational) exposures to lead.
Cross-sectional. Backwards
elimination multivariate regression
models that considered age, race,
education, retirement status, measures
of both current and cumulative
smoking, and alcohol consumption.
Normative Aging Study (n = 70).
Aim to examine age and secular
trends in bone and PbB levels of
community-exposed men aged 52-83
yr. Bone and PbB levels measured
twice, with a 3-yr interval.
Normative Aging Study (n = 747).
Aim to examine relationships of
nutritional factors to body Pb burden.
Cross-sectional.
Multiple regression models adjusting
for age, education level, smoking, and
alcohol consumption.
Lead Measurement (SD or range)
PbB in µg/dL, Bone Pb in µg/g Bone Mineral Findings, Interpretation
47-59 yr: (n = 116): PbB 5.8 (±3.7), tibia 14.6 (±8.3),
patella 23.6 (±12.4)
60-69 yr: (n = 360): PbB 6.3 (±4.2), tibia 21.1
(±11.4), patella 30.5 (±16.9)
>70 yr: (n = 243): PbB 6.5 (±4.5), tibia 27 (±15.6),
patella 38.8 (±23.5)
PbB 6.7 (±1.8), tibia 17.5 (±2.0), patella 29.1 (±1.8)
3 yr later: PbB 5.1 (±1.4), tibia 17.9 (±1.7), patella
22.2 (±1.8)
PbB 6.2 (± 4.1), tibia 21.9 (± 13.3), patella
32.0 (±19.5).
Multiple regression models men in the lowest quintile
of total dietary intake levels of vitamin D (including
vitamin supplements) (