Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX6-230
Table 6-9.2 (cont’d). Effects of Lead on Biochemical Effects in Adults
Reference, Study
Location, and Period Study Description Pb Measurement Findings, Interpretation
Asia (cont’d)
Schwartz et al. (1997)
Korea
1994-1995
Gurer-Orhan et al.
(2004)
Turkey
NR
Süzen et al. (2003)
Turkey
NR
Design: cross-sectional
Subjects: adult male battery manufacture
workers (n = 57), mean age 32 yrs (SD 6).
Outcome measures: blood Hgb, HgbA1, and
Hgb A2, ALAD genotype
Analysis: comparison of outcome measures
between ALAD genotype strata
Design: cross-sectional cohort
Subjects: adult male battery manufacture
workers (n = 20), mean age 35 yr (SD 8);
reference workers (n = 16), mean age
32 yr (SD 9)
Outcome measures: blood ALAD, EP,
erythrocyte MDA, CAT, G6PD, blood
GSH:GSSG
Analysis: comparison of outcome measures
between Pb workers and reference group,
correlation
Design: cross-sectional
Subjects: Male Pb battery manufacture
workers (n = 72), age range 24-45 yrs.
Outcome measures: blood ALAD, urine ALA,
ALAD genotype
Analysis: comparison of outcome measures
between ALAD genotype strata
Blood Pb (µg/dL) mean
(SD):
ALAD1,1 (n = 38): 26.1
(9.8)
ALAD1,2 (n = 19): 24.0
(11.3)
Blood Pb (µg/dL) mean
(SD):
Pb: 54.6 (17)
Reference: 11.8 (3.2)
Blood Pb (µg/dL) mean
(SD, range):
All: 34.5 (12.8, 13.4–71.8)
ALAD1,1 (n = 51)
34.4 (13.1, 13.4–71.8)
ALAD2 (n = 21)
34.9 (12.6, 19.2–69.6)
Mean blood Pb (p = 0.48) and blood Hgb levels (p = 0.34) were
not different between ALAD genotype strata.
Significant correlation between blood Pb concentration and blood
ALAD (r = -0.85, p < 0.0001) and EP (r = 0.83, p < 0.001).
Significant correlation between blood Pb concentration and
erythrocyte MDA (r = 0.80, p =