Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX6-229
Table 6-9.2 (cont’d). Effects of Lead on Biochemical Effects in Adults
Reference, Study
Location, and Period Study Description Pb Measurement Findings, Interpretation
Asia (cont’d)
Sugawara et al. (1991)
Japan
NR
Kim et al. (2002)
Korea
1996
Lee et al. (2000)
Korea
NR
Design: cross-sectional cohort
Subjects: adult Pb workers and reference
group (n = 32, total), ages NR
Outcome measures: plasma and erythrocyte
lipoperoxide and SOD; erythrocyte CAT,
GSH, and methemoglobin
Analysis: comparisons of outcome measures
between Pb workers and reference group,
linear regression and correlation
Design: cross-sectional cohort
Subjects: adult male secondary Pb smelter
workers (n = 83), mean age: 38.7 yr (SD
10.8); reference subjects (n = 24), mean age:
32.0 (SD 10.8)
Outcome measures: blood Hgb, blood ALAD,
blood EP, blood P5N
Analysis: parametric comparison (ANOVA)
of outcome measures between Pb workers and
reference group, correlation, multivariate
linear regression
Design: cross-sectional cohort
Subjects: adult male Pb workers (n = 95;
secondary smelter, PVC-stabilizer
manufacture, battery manufacture); mean age
42.8 yr (SD 9.3, range 19–64); reference group
(n = 13), mean age 35.1 yr (SD 9.9, range
22–54)
Outcome measures: urinary ALA, EP
Analysis: correlation
Blood Pb (µg/dL) mean
(SD, range):
Pb: 57.1 (17.6, 20–96)
Reference: NR
Blood Pb (µg/dL) mean
(SD)
Pb: 52.4 (17.7)
Reference: 6.2 (2.8)
Blood Pb (µg/dL) mean
(SD, range):
Pb: 44.6 (12.6, 21.4–78.4)
Reference: 5.9
(1.2, 4.0–7.2)
Significantly (p < 0.01) higher erythrocyte LPO and lower SOD,
CAT and GSH levels in workers compared to reference group.
Erythrocyte lipoperoxide (r = 0.656) and GSH (r = −0.631) were
significantly correlated with blood Pb.
Significantly (p < 0.05) lower blood P5N, ALAD, and Hgb; and
higher blood EP in Pb workers compared to controls.
Significant (p < 0.001) correlations (in Pb worker group) with
blood Pb: P5N (r = −0.704), log EP (r = 0.678), log ALAD
(r = −0.622).
Significant association between increasing EP and decreasing
blood Hgb:
blood Pb ∃60 µg/dL: ∃ = −1.546 (95% CI: −2.387, −0.704),
r 2 = 0.513, p = 0.001
blood Pb