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Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

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AX6-174<br />

Table AX6-6.2. <strong>Lead</strong> Exposure and Male Reproduction: Semen <strong>Quality</strong><br />

Reference and<br />

Study Location Study Description Pb Measurement Findings, Interpretation<br />

United States<br />

Ben<strong>of</strong>f et al. (2003a)<br />

New York<br />

Ben<strong>of</strong>f et al. (2003b)<br />

New York<br />

Cullen et al. (1984)<br />

U.S.<br />

74 male partners <strong>of</strong> women undergoing<br />

their first in vitro fertilization cycle.<br />

15 semen donors in an artificial<br />

insemination program. None were<br />

occupationally exposed to Pb.<br />

Seven men with symptomatic occupational<br />

Pb intoxication.<br />

Seminal plasma Pb:<br />

Mean 39.50 µg/dL (SD 35.97)<br />

Seminal plasma Pb:<br />

Range 150 µg/dL<br />

Maximum whole blood Pb levels:<br />

66-139 µg/dL<br />

Significant negative correlation between seminal<br />

plasma Pb and fertilization rate (r = !0.447).<br />

Statistically significant inverse correlations (r<br />

values <strong>of</strong>

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