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Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

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AX4-17<br />

Table AX4-5 (cont’d). Bone <strong>Lead</strong> Measurements in Occupationally-Exposed Subjects<br />

Reference, Study<br />

Location, and Period Study Description<br />

Europe (cont’d)<br />

Roels et al. (1995)<br />

Belgium<br />

Mexico<br />

Juarez-Perez et al.<br />

(2004)<br />

Mexico City<br />

1996-7<br />

Asia<br />

Schwartz et al. (2001)<br />

Korea<br />

1997-99<br />

Pb smelter and others.<br />

Active production (n = 73); Other<br />

departments (n = 50). K-shell measures<br />

with 109 Cd source. Cumulative PbB index.<br />

Lithographic print shop workers; Males,<br />

n = 59, 10 females; mean age 47 yrs<br />

Plasma Pb by ultraclean ICP-MS methods.<br />

K-shell measures with 109 Cd source.<br />

Korean Pb workers (798, 639 male,<br />

164 female) and controls (135, 124 male,<br />

1 female). Evaluation <strong>of</strong> associations<br />

between PbB, tibia Pb, chelatable Pb, and<br />

neurobehavioral functions. K-shell<br />

measures with 109 Cd source.<br />

<strong>Lead</strong> Measurement (SD or range)<br />

PbB in µg/dL, Bone Pb in µg/g Bone Mineral Findings, Interpretation<br />

Active: PbB 42.0, tibia 66.5<br />

Others: PbB 14.5, tibia 31.4<br />

PbB 11.9 (±5.8), tibia 27.6 (±18.1; ND-73.8),<br />

patella 46.8 (±29.3; ND-139)<br />

Active: PbB 32 (±15), tibia 37.2 (±40.4)<br />

Controls: PbB 5.3 (±1.8), tibia 5.8 (±7.0).<br />

Strong relationship between bone Pb and<br />

cumulative PbB index in smelter<br />

populations (r = 0.80, p < 0.0001; age<br />

explained #9.5% <strong>of</strong> variance). Slope <strong>of</strong><br />

regression equation <strong>of</strong> log bone Pb versus<br />

log cumulative PbB index showed that<br />

doubling <strong>of</strong> cumulative PbB index<br />

corresponds to doubling <strong>of</strong> bone Pb.<br />

Statistically significant associations<br />

between: plasma Pb and PbB, patella Pb,<br />

tibia Pb, age, education, use <strong>of</strong> Pb-glazed<br />

ceramics but not air Pb, hand Pb or hygiene<br />

index at work. Multiple linear regression<br />

models with patella and tibia Pb as main<br />

predictors and adjusting <strong>for</strong> PbB and<br />

hygiene index explained 57% <strong>of</strong> variability<br />

in plasma Pb. Negative association<br />

between plasma Pb and hygiene index<br />

suggest oral exposure and gastrointestinal<br />

uptake <strong>of</strong> Pb predominant source <strong>of</strong> Pb<br />

exposure in these subjects.<br />

After adjustment <strong>for</strong> covariates, tibia Pb<br />

was not associated with neurobehavioral<br />

test scores.

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