Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX6-81
Table AX6-4.2. Renal Effects of Lead in the Occupational Population
Reference, Study
Location, and
Period Study Description Pb Measurement Findings, Interpretation
United States
Smith et al. (1995)
U.S.
Study date not
provided
Europe
Bergdahl et al. (1997)
Sweden
Study date not
provided
691 construction workers.
96 participants with the ALAD2 allele.
89 Pb workers; 7 had the ALAD2 allele.
34 controls; 10 had the ALAD2 allele.
Mean blood Pb
7.8 µg/dL (ALAD11)
7.7 µg/dL (ALAD12 or 22)
Median blood Pb
31.1 µg/dL in Pb workers
with ALAD11
28.8 µg/dL in Pb workers
with ALAD12 or 22
3.7 µg/dL in control workers
with ALAD11
3.7 µg/dL in control workers
with ALAD12 or 22
Higher mean BUN (p = 0.03) in participants with the
ALAD2 allele compared to those with the ALAD11
genotype. However, after adjustment for age, alcohol
ingestion, and blood Pb, the association was no longer
significant. Effect modification was not evaluated.
Higher crude mean serum creatinine (p = 0.11) in
participants with the ALAD2 allele compared to those
with the ALAD11 genotype. Adjusted data not presented.