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Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

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AX6-68<br />

Table AX6-3.9 (cont’d). Other Neurological Outcomes Associated with <strong>Lead</strong> Exposure in Adults<br />

Reference, Study<br />

Location, and Period Study Description Pb Measurement Findings, Interpretation<br />

Europe (cont’d)<br />

Guidetti et al. (1996)<br />

Italy<br />

Vinceti et al. (1997)<br />

Italy<br />

A retrospective incidence, prevalence, and<br />

mortality survey <strong>of</strong> ALS in northern Italy<br />

was per<strong>for</strong>med.<br />

19 ALS cases, mean age 66 (14) yrs and<br />

39 controls, mean age 64 (12.9) yrs.<br />

Mean air Pb 3 µg/m 3 in<br />

1975 to 1 µg/m 3 in 1985;<br />

blood Pb in monitored<br />

children decreased 18, 14,<br />

and 11 µg/dL in same time<br />

period.<br />

Sporadic ALS<br />

Mean (SD) blood Pb 13<br />

(6.8) µg/dL<br />

Controls<br />

Mean (SD) blood Pb<br />

11 (4.4) µg/dL<br />

The area studied had documented Pb pollution <strong>for</strong> yrs. Based upon<br />

79 cases incidence and prevalence rate were comparable to the<br />

surrounding area.<br />

There were no cases familial ALS. Blood Pb between ALS cases<br />

and controls was not significantly different. Blood Pb was associated<br />

with disability due to ALS but no support was found <strong>for</strong> involvement<br />

<strong>of</strong> Pb in the etiology <strong>of</strong> sporadic ALS.

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