Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

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Dearth, R. K.; Hiney, J. K.; Srivastava, V.; Les Dees, W.; Bratton, G. R. (2004) Low level lead (Pb) exposure during gestation and lactation: assessment of effects on pubertal development in Fisher 344 and Sprague-Dawley female rats. Life Sci. 74: 1139-1148. Degawa, M.; Arai, H.; Miura, S.; Hashimoto, Y. (1993) Preferential inhibitions of hepatic P450IA2 expression and induction by lead nitrate in the rat. Carcinogenesis (London) 14: 1091-1094. Degawa, M.; Arai, H.; Kubota, M.; Hashimoto, Y. (1994) Ionic lead, a unique metal ion as an inhibitor for cytochrome P450IA2 (CYP1A2) expression in the rat liver. Biochem. Biophys. Res. Commun. 200: 1086-1092. Degawa, M.; Arai, H.; Kubota, M.; Hashimoto, Y. (1995) Ionic lead, but not other ionic metals (Ni2+, Co2+ and Cd2+), suppresses 2-methoxy-4-aminoazobenzene-mediated cytochrome P450IA2 (CYP1A2) induction in rat liver. Biol. Pharm. Bull. 18: 1215-1218. Degawa, M.; Matsuda, K.; Arai, H.; Hashimoto, Y. (1996) Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver. J. Biochem. (Tokyo, Jpn.) 120: 547-551. Dehpour, A. R.; Essalat, M.; Ala, S.; Ghazi-Khansari, M.; Ghafourifar, P. (1999) Increase by NO synthase inhibitor of lead-induced release of N-acetyl-β-D-glucosaminidase from perfused rat kidney. Toxicology 132: 119-125. Dekaney, C. M.; Harris, E. D.; Bratton, G. R.; Jaeger, L. A. (1997) Lead transport in IEC-6 intestinal epithelial cells. Biol. Trace Elem. Res. 58: 13-24. Delville, Y. (1999) Exposure to lead during development alters aggressive behavior in golden hamsters. Neurotoxicol. Teratol. 21: 445-449. Deng, W.; Poretz, R. D. (2002) Protein kinase C activation is required for the lead-induced inhibition of proliferation and differentiation of cultured oligodendroglial progenitor cells. Brain Res. 929: 87-95. Deng, W.; McKinnon, R. D.; Poretz, R. D. (2001) Lead exposure delays the differentiation of oligodendroglial progenitors in vitro. Toxicol. Appl. Pharmacol. 174: 235-244. Dentener, M. A.; Greve, J. W.; Maessen, J. G.; Buurman, W. A. (1989) Role of tumour necrosis factor in the enhanced sensitivity of mice to endotoxin after exposure to lead. Immunopharmacol. Immunotoxicol. 11: 321-334. Dessi, S.; Batetta, B.; Laconi, E.; Ennas, C.; Pani, P. (1984) Hepatic cholesterol in lead nitrate induced liver hyperplasia. Chem. Biol. Interact. 48: 271-279. Dessi, S.; Batetta, B.; Pulisci, D.; Carrucciu, A.; Mura, E.; Ferreli, A.; Pani, P. (1990) Modifying influence of fasting on liver hyperplasia induced by lead nitrate. Res. Commun. Chem. Pathol. Pharmacol. 68: 103-116. Devi, K. D.; Banu, B. S.; Grover, P.; Jamil, K. (2000) Genotoxic effect of lead nitrate on mice using SCGE (comet assay). Toxicology 145: 195-201. Dey, S.; Arjun, J.; Das, M.; Bhattacharjee, C. R.; Dkhar, P. S. (2001) Effect of prenatal lead toxicity on surface ultrastructural features, elemental composition and infrared absorption characteristics of the skin of albino mice. Cytobios 106(suppl. 2): 245-254. Dhir, H.; Roy, A. K.; Sharma, A.; Talukder, G. (1990) Modification of clastogenicity of lead and aluminium in mouse bone marrow cells by dietary ingestion of Phyllanthus emblica fruit extract. Mutat. Res. 241: 305-312. Dhir, H.; Ghosh, S.; Sharma, A.; Talukder, G. (1992a) Interaction between two group IV metals: - lead and zirconium - in bone marrow cells of Mus musculus in vivo. Biometals 5: 81-86. Dhir, H.; Sharma, A.; Talukder, G. (1992b) Modifying effect of iron on lead-induced clastogenicity in mouse bone marrow cells. Biol. Trace Elem. Res. 34: 279-286. Dhir, H.; Roy, A. K.; Sharma, A. (1993) Relative efficiency of Phyllanthus emblica fruit extract and ascorbic acid in modifying lead and aluminium-induced sister-chromatid exchanges in mouse bone marrow. Environ. Mol. Mutagen. 21: 229-236. Diamond, G. L.; Goodrum, P. E.; Felter, S. P.; Ruoff, W. L. (1998) Gastrointestinal absorption of metals. Drug Chem. Toxicol. 21: 223-251. Dieter, M. P.; Matthews, H. B.; Jeffcoat, R. A.; Moseman, R. F. (1993) Comparison of lead bioavailability in F344 rats fed lead acetate, lead oxide, lead sulfide, or lead ore concentrate from Skagway, Alaska. J. Toxicol. Environ. Health 39: 79-93. Dietert, R. R.; Piepenbrink, M. S. (2006) Perinatal immunotoxicity: why adult exposure assessment fails to predict risk. Environ. Health Perspect. 114: 477-483. Dietert, R. R.; Etzel, R. A.; Chen, D.; Halonen, M.; Holladay, S. D.; Jarabek, A. M.; Landreth, K.; Peden, D. B.; Pinkerton, K.; Smialowicz, R. J.; Zoetis, T. (2000) Workshop to identify critical window of exposure for AX5-199
children's health: immune and respiratory systems work group summary. Environ. Health Perspect. Suppl. 108(3): 483-490. Dietert, R. R.; Lee, J.-E.; Bunn, T. L. (2002) Developmental immunotoxicology: emerging issues. Hum. Exp. Toxicol. 21: 479-485. Dietert, R. R.; Lee, J.-E.; Hussain, I.; Piepenbrink, M. (2004) Developmental immunotoxicology of lead. Toxicol. Appl. Pharmacol. 86-94. Ding, Y.; Vaziri, N. D.; Gonick, H. C. (1998) Lead-induced hypertension. II. Response to sequential infusions of L-arginine, superoxide dismutase, and nitroprusside. Environ. Res. 76: 107-113. Ding, Y.; Gonick, H. C.; Vaziri, N. D. (2000) Lead promotes hydroxyl radical generation and lipid peroxidation in cultured aortic endothelial cells. Am. J. Hypertens. 13: 552-555. Ding, Y.; Gonick, H. C.; Vaziri, N. D.; Liang, K.; Wei, L. (2001) Lead-induced hypertension. III. Increased hydroxyl radical production. Am. J. Hypertens. 14: 169-173. Dini, L.; Falasca, L.; Lentini, A.; Mattioli, P.; Piacentini, M.; Piredda, L.; Autuori, F. (1993) Galactose-specific receptor modulation related to the onset of apoptosis in rat liver. Eur. J. Cell. Biol. 61: 329-337. Dini, L.; Giudetti, A. M.; Ruzittu, M.; Gnoni, G. V.; Zara, V. (1999) Citrate carrier and lipogenic enzyme activities in lead nitrate-induced proliferative and apoptotic phase in rat liver. Biochem. Mol. Biol. Int. 47: 607-614. Dock, L. (1989) Induction of rat liver glutathione transferase isoenzyme 7-7 by lead nitrate. Biol. Trace Elem. Res. 21: 283-288. Donald, J. M.; Cutler, M. G.; Moore, M. R.; Bardley, M. (1986) Effects of lead in the laboratory mouse—2: development and social behaviour after lifelong administration of a small dose of lead acetate in drinking fluid. Neuropharmacology 25: 151-160. Donald, J. M.; Cutler, M. G.; Moore, M. R. (1987) Effects of lead in the laboratory mouse. Development and social behaviour after lifelong exposure to 12 µM lead in drinking fluid. Neuropharmacology 26: 391-399. Donaldson, W. E.; Leeming, T. K. (1984) Dietary lead: effects on hepatic fatty acid composition in chicks. Toxicol. Appl. Pharmacol. 73: 119-123. Donaldson, J.; Hemming, R.; LaBella, F. (1985) Vanadium exposure enhances lipid peroxidation in the kidney of rats and mice. Can. J. Physiol. Pharmacol. 63: 196-199. Dorman, R. V.; Freeman, E. J. (2002) Lead-dependent effects on arachidonic acid accumulation and the proliferation of vascular smooth muscle. J. Biochem. Mol. Toxicol. 16: 245-253. Dorward, A.; Yagminas, A. P. (1994) Activity of erythrocyte δ-aminolevulinic acid dehydratase in the female cynomolgus monkey (Macaca fascicularis): kinetic analysis in control and lead-exposed animals. Comp. Biochem. Physiol. B: Biochem. Mol. Biol. 108: 241-252. Dowd, T. L.; Rosen, J. F.; Gupta, R. K. (1990) 31P NMR and saturation transfer studies of the effect of PB2+ on cultured osteoblastic bone cells. J. Biol. Chem. 265: 20833-20838. Dowd, T. L.; Rosen, J. F.; Gundberg, C. M.; Gupta, R. K. (1994) The displacement of calcium from osteocalcin at submicromolar concentrations of free lead. Biochim. Biophys. Acta 1226: 131-137. Dowd, T. L.; Rosen, J. F.; Mints, L.; Gundberg, C. M. (2001) The effect of Pb2+ on the structure and hydroxyapatite binding properties of osteocalcin. Biochim. Biophys. Acta 1535: 153-163. Dunon, D.; Allioli, N.; Vainio, O.; Ody, C.; Imhof, B. A. (1998) Renewal of thymocyte progenitors and emigration of thymocytes during avian development. Dev. Comp. Immunol. 22: 279-287. Dursun, N.; Arifoglu, C.; Süer, C.; Keskinol, L. (2005) Blood pressure relationship to nitric oxide, lipid peroxidation, renal function, and renal blood flow in rats exposed to low lead levels. Biol. Trace Elem. Res. 104: 141-150. DuVal, G.; Fowler, B. A. (1989) Preliminary purification and characterization studies of a low molecular weight, high affinity cytosolic lead-binding protein in rat brain. Biochem. Biophys. Res. Commun. 159: 177-184. Duydu, Y.; Süzen, H. S.; Aydin, A.; Cander, O.; Uysal, H.; Isimer, A.; Vural, N. (2001) Correlation between lead exposure indicators and sister chromatid exchange (SCE) frequencies in lymphocytes from inorganic lead exposed workers. Arch. Environ. Contam. Toxicol. 41: 241-246. Dyatlov, V. A.; Lawrence, D. A. (2002) Neonatal lead exposure potentiates sickness behavior induced by Listeria monocytogenes infection of mice. Brain Behav. Immun. 16: 477-492. Dyatlov, V. A.; Platoshin, A. V.; Lawrence, D. A.; Carpenter, D. O. (1998a) Lead potentiates cytokine- and glutamate-mediated increases in permeability of the blood-brain barrier. Neurotoxicology 19: 283-292. Dyatlov, V. A.; Dyatlova, O. M.; Parsons, P. J.; Lawrence, D. A.; Carpenter, D. O. (1998b) Lipopolysaccharide and interleukin-6 enhance lead entry into cerebellar neurons: application of a new and sensitive flow cytometric technique to measure intracellular lead and calcium concentrations. Neurotoxicology 19: 293-302. AX5-200
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October 2006 EPA/600/R-05/144bF Air
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PREFACE National Ambient Air Qualit
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NCEA acknowledges the valuable cont
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Table of Contents Page PREFACE ....
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Authors, Contributors, and Reviewer
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Contributors and Reviewers (cont’
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Contributors and Reviewers (cont’
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Executive Direction U.S. Environmen
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Chair U.S. Environmental Protection
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Abbreviations and Acronyms αFGF α
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BLL blood lead level BLM biotic lig
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CRI chronic renal insufficiency CSF
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EPT macroinvertebrates from the Eph
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GRP78 glucose-regulated protein 78
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KABC Kaufman Assessment Battery for
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NADP nicotinamide adenine dinucleot
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Pb(Ac)2 lead acetate PbB blood lead
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RR RT RSEM RSUC RT ∑SEM SA7 SAB S
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TGF transforming growth factor TH t
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AX4. CHAPTER 4 ANNEX ANNEX TABLES A
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AX4-3 Table AX4-1 (cont’d). Analy
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AX4-5 Table AX4-2 (cont’d). Summa
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AX4-7 Table AX4-3. Bone Lead Measur
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AX4-9 Reference, Study Location, an
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AX4-11 Table AX4-4 (cont’d). Bone
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AX4-19 Reference, Study Location, a
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AX4-37 Table AX4-9 (cont’d). Lead
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AX4-39 Table AX4-11. Summary of Sel
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AX4-41 Table AX4-11 (cont’d). Sum
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AX-43 Table AX4-12 (cont’d). Summ
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Barltrop, D.; Meek, F. (1979) Effec
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Carroll, R. J.; Galindo, C. D. (199
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Flegal, A. R.; Smith, D. R. (1995)
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Gulson, B.; Mizon, K.; Smith, H.; E
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Khoury, G. A.; Diamond, G. L. (2003
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Morgan, W. D.; Ryde, S. J.; Jones,
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Pounds, J. G.; Leggett, R. W. (1998
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Skerfving, S. (1988) Biological mon
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U.S. Environmental Protection Agenc
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Air Quality Criteria for Lead Volum
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AQCD/Addendum and 1990 Supplement,
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Air Quality Criteria for Lead (Seco
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List of Tables AX4-1 Analytical Met
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List of Tables (cont’d) AX5-6.3 G
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List of Tables (cont’d) AX5-9.3 S
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Principal Authors (cont’d) Author
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Principal Authors Authors, Contribu
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Principle Authors (cont’d) Author
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Technical Support Staff U.S. Enviro
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Members (cont’d) U.S. Environment
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ANP atrial natriuretic peptide AP a
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CCE Coordination Center for Effects
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DR drinking water DSA delayed spati
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FTII Fagan Test of Infant Intellige
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H3PO4 phosphoric acid HPRT hypoxant
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MATC maximum acceptable threshold c
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NOS nitric oxide synthase; not othe
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PPVT-R Peabody Picture Vocabulary T
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SOPR sperm-oocyte penetration rate
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vit C vitamin C vit E vitamin E VMA
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AX5-2 Table AX5-2.1. Effect of Lead
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AX5-4 Table AX5-2.1 (cont’d). Eff
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AX5-6 Table AX5-2.2. Lead, Erythroc
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AX5-8 Table AX5-2.2 (cont’d). Lea
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AX5-10 Table AX5-2.4. Lead Effects
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AX5-12 Table AX5-2.5. Lead Interact
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AX5-14 Table AX5-2.7. Lead, Erythro
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AX5-16 Subject Exposure Protocol Ra
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AX5-22 Subject Rat, female, 22 wks
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AX5-24 Subject Rat, F344, male Expo
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AX5-26 Subject Monkey, cynomolgus,
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AX5-28 Subject Rat, SD, male, PND 6
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AX5-30 Subject Monkey, cynomolgus,
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AX5-32 Subject Exposure Protocol Ta
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AX5-34 Table AX5-3.6 (cont’d). Ke
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AX5-36 Table AX5-3.6 (cont’d). Ke
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AX5-38 Citation Al-Hakkak et al. (1
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AX5-40 Citation Fox et al. (1997)
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AX5-42 Citation Pinon- Lataillade e
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AX5-44 Citation Wiebe et al. (1998)
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AX5-46 Citation Chowdhuri et al. (2
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AX5-48 Citation Graca et al. (2004)
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AX5-50 Citation Marchlewicz et al.
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AX5-52 Table AX5-4.2 (cont’d). Ef
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AX5-54 Citation Sokol et al. (1985)
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AX5-56 Citation Table AX5-4.3 (cont
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AX5-58 Citation Priya et al. (2004)
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ANNEX TABLES AX5-5 AX5-60
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AX5-62 Table AX5-5.1 (cont’d). In
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AX5-64 Table AX5-5.1 (cont’d). In
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AX5-66 Reference Watts et al. (1995
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AX5-68 Reference Lai et al. (2002)
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AX5-70 Reference Shelkovnikov and G
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AX5-72 Reference Fujiwara and Kaji
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AX5-74 Reference Fugiwara et al. (1
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AX5-76 Table AX5-6.1. Genotoxic/Car
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AX5-80 Table AX5-6.3 (cont’d). Ge
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AX5-86 Compound Table AX5-6.6. Geno
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AX5-96 Table AX5-6.10 (cont’d). G
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AX5-98 Table AX5-6.12. Genotoxic/Ca
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AX5-100 Table AX5-6.14. Genotoxic/C
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AX5-102 Compound Table AX5-6.16. Ge
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AX5-104 Table AX5-6.18. Genotoxic/C
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AX5-106 Table AX5-6.18 (cont’d).
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AX5-108 Table AX5-6.19 (cont’d).
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AX5-110 Compound Assay (Concentrati
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AX5-112 Table AX5-7.1. Light Micros
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AX5-114 Table AX5-7.2. Lead and Fre
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AX5-116 Table AX5-7.2 (cont’d). L
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AX5-118 Table AX5-7.4. Effect of Ch
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AX5-120 Table AX5-7.5 (cont’d). E
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AX5-122 Table AX5-8.1. Bone Growth
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AX5-124 Table AX5-8.1 (cont’d). B
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AX5-126 Table AX5-8.2. Regulation o
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AX5-128 Table AX5-8.2 (cont’d). R
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AX5-136 Table AX5-8.4. Bone Lead as
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AX5-142 Table AX5-8.5. Uptake of Le
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AX5-144 Table AX5-8.7. Effects of L
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Page 289 and 290: AX5-148 Nature of Exposure Table AX
Page 291 and 292: AX5-150 Table AX5-9.2. Effect of Le
Page 293 and 294: AX5-152 Species Strain/Gender Age M
Page 295 and 296: AX5-154 Table AX5-9.5 (cont’d). E
Page 297 and 298: ANNEX TABLES AX5-10 AX5-156
Page 299 and 300: AX5-158 Table AX5-10.1 (cont’d).
Page 303 and 304: AX5-162 Table AX5-10.2. Biochemical
Page 307 and 308: AX5-166 Table AX5-10.4. Lead, Oxida
Page 321 and 322: AX5-180 Table AX5-10.7. Lead and In
Page 325 and 326: AX5-184 Table AX5-10.9. Lead, Calci
Page 327 and 328: ANNEX TABLES AX5-11 AX5-186
Page 329 and 330: AX5-188 Source Organ Species Table
Page 331 and 332: REFERENCES Abdollahi, M.; Dehpour,
Page 333 and 334: Bataineh, H.; Al-Hamood, M. H.; Elb
Page 335 and 336: Buchet, J.-P.; Roels, H. E.; Huberm
Page 337 and 338: Cline, H. T.; Witte, S.; Jones, K.
Page 339: Cory-Slechta, D. A.; McCoy, L.; Ric
Page 343 and 344: Ferguson, C.; Kern, M.; Audesirk, G
Page 345 and 346: Fullmer, C. S. (1991) Intestinal ca
Page 347 and 348: Goyer, R. A.; Leonard, D. L.; Moore
Page 349 and 350: Hengstler, J. G.; Bolm-Audorff, U.;
Page 351 and 352: Jacquet, P.; Leonard, A.; Gerber, G
Page 353 and 354: Kim, K. A.; Chakraborti, T.; Goldst
Page 355 and 356: Laughlin, N. K.; Bowman, R. E.; Fra
Page 357 and 358: Maldonado-Vega, M.; Cerbón-Solórz
Page 359 and 360: Moorman, W. J.; Skaggs, S. R.; Clar
Page 361 and 362: O'Flaherty, E. J.; Inskip, M. J.; F
Page 363 and 364: Price, R. G.; Taylor, S. A.; Chiver
Page 365 and 366: Rodamilans, M.; Mtz.-Osaba, M. J.;
Page 367 and 368: Schlipkoter, H.-W.; Frieler, L. (19
Page 369 and 370: Skoczyńska, A.; Smolik, R.; Jeleń
Page 371 and 372: Tavakoli-Nezhad, M.; Pitts, D. K. (
Page 373 and 374: Valentino, M.; Governa, M.; Marchis
Page 375 and 376: Wetmur, J. G.; Lehnert, G.; Desnick
Page 377 and 378: Zhou, J.; Xu, Y.-H.; Chang, H.-F. (
Page 379 and 380: Air Quality Criteria for Lead Volum
Page 381 and 382: The purpose of this revised Lead AQ
Page 383 and 384: Air Quality Criteria for Lead (Seco
Page 385 and 386: List of Tables Number Page AX6-2.1
Page 387 and 388: List of Tables (cont’d) Number Pa
Page 389 and 390: Principal Authors Authors, Contribu
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ANOVA analysis of variance ANP atri
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CCD charge-coupled device CCE Coord
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DPPD N-N-diphenyl-p-phynylene-diami
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FTES free testosterone FTII Fagan T
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HPLC high-pressure liquid chromatog
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MAO monoamine oxidase MATC maximum
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NORs nucleolar organizing regions N
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ppm parts per million PPVT-R Peabod
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AX6-4 Table AX6-2.1 (cont’d). Pro
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AX6-10 Table AX6-2.2 (cont’d). Me
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AX6-12 Table AX6-2.3 (cont’d). Cr
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AX6-14 Table AX6-2.4. Effects of Le
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AX6-24 Table AX6-2.8. Effects of Le
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AX6-30 Table AX6-3.1. Neurobehavior
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AX6-32 Table AX6-3.1 (cont’d). Ne
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AX6-34 Table AX6-3.2 (cont’d). Sy
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AX6-36 Table AX6-3.3. Neurobehavior
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AX6-50 Table AX6-3.4 (cont’d). Me
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AX6-56 Table AX6-3.6. Evoked Potent
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AX6-58 Table AX6-3.6 (cont’d). Ev
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AX6-60 Table AX6-3.7 (cont’d). Po
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AX6-62 Table AX6-3.7 (cont’d). Po
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AX6-64 Table AX6-3.8 (cont’d). Oc
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AX6-66 Table AX6-3.9. Other Neurolo
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AX6-68 Table AX6-3.9 (cont’d). Ot
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AX6-70 Table AX6-4.1. Renal Effects
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AX6-72 Table AX6-4.1 (cont’d). Re
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AX6-104 Table AX6-4.3. Renal Effect
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AX6-166 Table AX6-5.4. Cardiovascul
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AX6-170 Table AX6-6.1 (cont’d). P
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AX172 Table AX6-6.1 (cont’d). Pla
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AX6-174 Table AX6-6.2. Lead Exposur
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AX6-176 Table AX6-6.2 (cont’d). L
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AX6-186 Table AX6-7.2. Key Occupati
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AX6-188 Table AX6-7.2 (cont’d). K
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AX6-190 Table AX6-7.2 (cont’d). K
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AX6-192 Table AX6-7.3. Key Studies
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AX6-194 Table AX6-7.4. Other Studie
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AX6-196 Table AX6-7.4 (cont’d). O
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AX6-224 Table 6-9.2 (cont’d). Eff
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AX6-232 Table AX6-9.3 (cont’d.).
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AX6-258 Table AX6-9.10. Effects of
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REFERENCES Abbate, C.; Buceti, R.;
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Baghurst, P. A.; McMichael, A. J.;
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Bolla, K. I.; Schwartz, B. S.; Stew
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Chia, K. S.; Jeyaratnam, J.; Tan, C
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David, O. J.; Clark, J.; Hoffman, S
Page 687 and 688:
Englyst, V.; Lundstrom, N. G.; Gerh
Page 689 and 690:
Gennart, J. P.; Bernard, A.; Lauwer
Page 691 and 692:
Haraguchi, T.; Ishizu, H.; Takehisa
Page 693 and 694:
Jemal, A.; Graubard, B. I.; Devesa,
Page 695 and 696:
Lanphear, B. P.; Howard, C.; Eberly
Page 697 and 698:
Lundström, N.-G.; Nordberg, G.; En
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Muntner, P.; He, J.; Vupputuri, S.;
Page 701 and 702:
Paksy, K.; Gáti, I.; Náray, M.; R
Page 703 and 704:
Rhainds, M.; Levallois, P.; Dewaill
Page 705 and 706:
Sargent, J. D.; Dalton, M. A.; O'Co
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Sheffet, A.; Thind, I.; Miller, A.
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Stevens, L. A.; Levey, A. S. (2005b
Page 711 and 712:
Van Larebeke, N.; Koppen, G.; Nelen
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Winker, R.; Ponocny-Seliger, E.; R
Page 715 and 716:
October 2006 EPA/600/R-05/144bF Air
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PREFACE National Ambient Air Qualit
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drafts of document materials were r
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Table of Contents PREFACE..........
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Table of Contents (cont’d) II-ix
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List of Tables (cont’d) AX7-2.3.1
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List of Figures (cont’d) Number P
Page 729 and 730:
Page 731 and 732:
Page 733 and 734:
Page 735 and 736:
Page 737 and 738:
Page 739 and 740:
ANOVA analysis of variance ANP atri
Page 741 and 742:
CCD charge-coupled device CCE Coord
Page 743 and 744:
DPPD N-N-diphenyl-p-phynylene-diami
Page 745 and 746:
FTES free testosterone FTII Fagan T
Page 747 and 748:
HPLC high-pressure liquid chromatog
Page 749 and 750:
MAO monoamine oxidase MATC maximum
Page 751 and 752:
NORs nucleolar organizing regions N
Page 753 and 754:
ppm parts per million PPVT-R Peabod
Page 755 and 756:
Page 757 and 758:
Page 759 and 760:
Pb is ideally suited for this task.
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Concept For a given metal or metall
Page 763 and 764:
(1979) observed that “the smaller
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Figure AX7-1.1.3. Illustration of p
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• Colorimetric • Electrochemica
Page 769 and 770:
Figure AX7-1.1.5. Bulk lead versus
Page 771 and 772:
diffraction lines and comparing the
Page 773 and 774:
The major disadvantage of SIMS to s
Page 775 and 776:
techniques can be useful in a study
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have included phosphoric acid (H3PO
Page 779 and 780:
to 15 years after biosolid applicat
Page 781 and 782:
thin films (DGT), and ICP technique
Page 783 and 784:
completely extract targeted phases.
Page 785 and 786:
epresents Eb. The precise energy re
Page 787 and 788:
1974; Ruby et al., 1994). However,
Page 789 and 790:
T1/2 = 14 × 10 9 year). The result
Page 791 and 792:
floor) time-series data to evaluate
Page 793 and 794:
contributions of dry deposition may
Page 795 and 796:
Compared to their estimated 20th-ce
Page 797 and 798:
thought to enter the plant via the
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soil was not allowed to equilibrate
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Lead concentrations in various tiss
Page 803 and 804:
that the nematode may detoxify Pb v
Page 805 and 806:
plasma levels of uric acid and crea
Page 807 and 808:
effective use of glutathione metabo
Page 809 and 810:
and oats (Avena sativa) had signifi
Page 811 and 812:
other metals is inconsistent (Påhl
Page 813 and 814:
Speciation and Form of Lead Recent
Page 815 and 816:
organism responses to Pb. Section A
Page 817 and 818:
Primary Producers Commonly reported
Page 819 and 820:
solution and minimal translocation
Page 821 and 822:
AX7.1.3.3 Recent Studies on the Eff
Page 823 and 824:
AX7-66 Avian Species Reproduction J
Page 825 and 826:
AX7-68 Avian Species American kestr
Page 827 and 828:
Very little research has been done
Page 829 and 830:
AX7-72 Mammalian Species Reproducti
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AX7-74 Mammalian Species No. of Dos
Page 833 and 834:
Page 835 and 836:
Page 837 and 838:
AX7-80 Mammalia n Species No. of Do
Page 839 and 840:
A literature search and review was
Page 841 and 842:
Table AX7-1.3.6. Invertebrate Toxic
Page 843 and 844:
The effects of Pb-chloride on the p
Page 845 and 846:
Ecological Soil Screening Levels (E
Page 847 and 848:
Since the movement and fate of Pb i
Page 849 and 850:
Land Use and Industry Changes in la
Page 851 and 852:
lakes in the United Kingdom the dis
Page 853 and 854:
zinc; had very low pH; and were det
Page 855 and 856:
Sites Affected by Long-Range Lead T
Page 857 and 858:
iomass carbon. Because of this link
Page 859 and 860:
in an oak woodland site 3 km from a
Page 861 and 862:
the forested Lehstenbach catchment
Page 863 and 864:
there is little evidence that Pb ac
Page 865 and 866:
ecosystems. Just as in the terrestr
Page 867 and 868:
To develop chronic AWQC, acceptable
Page 869 and 870:
for the binding of free-metal ion a
Page 871 and 872:
partition in sediment between acid-
Page 873 and 874:
AX7.2.1.5 Metal Mixtures As discuss
Page 875 and 876:
varies from 4:1 in rural streams to
Page 877 and 878:
Organic compounds in surface waters
Page 879 and 880:
solution phase, complexation with c
Page 881 and 882:
The NAWQA dataset was chosen over o
Page 883 and 884:
Lead Distributions Generated from t
Page 885 and 886:
AX7-128 Figure AX7-2.2.3. Spatial d
Page 887 and 888:
AX7-130 Figure AX7-2.2.5. Spatial d
Page 889 and 890:
AX7-132 ` Figure AX7-2.2.7. Spatial
Page 891 and 892:
Figure AX7-2.2.8. Frequency distrib
Page 893 and 894:
Table AX7-2.2.4. Summary Statistics
Page 895 and 896:
Table AX7-2.2.5. Comparison of NCBP
Page 897 and 898:
AX7-140 Figure AX7-2.2.13. Spatial
Page 899 and 900:
calculations indicate that only a s
Page 901 and 902:
from municipal sewage, storm runoff
Page 903 and 904:
AX7.2.3 Aquatic Species Response/Mo
Page 905 and 906:
aquatic plants and insects and on t
Page 907 and 908:
designed to model uptake, MINTEQ pr
Page 909 and 910:
sequestering to organ tissues). The
Page 911 and 912:
AbdAllah and Moustafa (2002) studie
Page 913 and 914:
Summary of Detoxifiction Processes
Page 915 and 916:
1.1 µg/L Cd, 12 µg/L Cu, 55 µg/L
Page 917 and 918:
Studies have identified ALAD in fis
Page 919 and 920:
metals over nonessential metals. Th
Page 921 and 922:
In summary, relationships between a
Page 923 and 924:
potential toxic effects in other or
Page 925 and 926:
esulted in 91.7% survival (Horne an
Page 927 and 928:
carbon sources (including glucose),
Page 929 and 930:
separate concentration-effects mode
Page 931 and 932:
1994. mSQGQs are useful to risk ass
Page 933 and 934:
Algae The 1986 Lead AQCD (U.S. Envi
Page 935 and 936:
observed in Selenastrum capricornut
Page 937 and 938:
Nitrate uptake reported after 48, 7
Page 939 and 940:
1997). The most sensitive primary p
Page 941 and 942:
Freshwater Invertebrates Acute and
Page 943 and 944:
AX7-186 Amphipod (Hyalella azteca)
Page 945 and 946:
concentrations of
Page 947 and 948:
AX7-190 Freshwater Species Chemical
Page 949 and 950:
AX7-192 Species Chemical Frogs (Ran
Page 951 and 952:
studied using Spirodela polyrhiza,
Page 953 and 954:
However, in other cases multivariat
Page 955 and 956:
species was observed. Similar, sign
Page 957 and 958:
AX7-200 Table AX7-2.5.2. Essential
Page 959 and 960:
AX7-202 Table AX7-2.5.2 (cont’d).
Page 961 and 962:
variables, it does not imply causat
Page 963 and 964:
Poulton et al. (1995), the effects
Page 965 and 966:
metal levels. Furthermore, although
Page 967 and 968:
environment through bioaccumulation
Page 969 and 970:
Angle, C. R.; McIntire, M. S.; Colu
Page 971 and 972:
Black, M. C.; Ferrell, J. R.; Horni
Page 973 and 974:
Clements, W. H. (1994) Benthic inve
Page 975 and 976:
Ekenler, M.; Tabatabai, M. (2002) E
Page 977 and 978:
Getz, L. L.; Haney, A. W.; Larimore
Page 979 and 980:
Houlton, B. Z.; Driscoll, C. T.; Fa
Page 981 and 982:
Krüger, F.; Gröngröft, A. (2003)
Page 983 and 984:
Manceau, A.; Lanson, B.; Schlegel,
Page 985 and 986:
Niyogi, S.; Wood, C. M. (2003) Effe
Page 987 and 988:
Rand, G. M.; Wells, P. G.; McCarty,
Page 989 and 990:
Scherer, E.; McNicol, R. E. (1998)
Page 991 and 992:
Sturges, W. T.; Barrie, L. A. (1987
Page 993 and 994:
U.S. Environmental Protection Agenc
Page 995 and 996:
Zenk, M. H. (1996) Heavy metal deto
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