Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX5-154
Table AX5-9.5 (cont’d). Effect of Lead on Mitogen-induced Lymphoid Proliferation
Species Strain/ Gender Age Proliferation Effects
Mouse C57 Bl/6 males Adult ↓PHA
Rat SD females Neonatal–
Juveniles
↓ConA
LPS No change
↓PHA
↓ConA
In Vivo/
Ex Vivo Lead Dose/ Concentration
Duration
of Exposure References
Yes 1,300 ppm 8 wks Neilan et al. (1980)
Yes 25 ppm 6 wks Faith et al. (1979)
Mouse BALB/c Adult ↑LPS No 10 −5 –10 −3 M 3 days Gallagher et al. (1979)
Mouse Swiss males Adult ↓PHA
↓PWM
Mouse Swiss males Adult ↑PHA
↑PWM
Yes 2,000 ppm 30 days Gaworski and Sharma (1978)
No 0.1 mM–1.0 mM 2–3 days Gaworski and Sharma
(1978)
Mouse CBA/J Adult ↑LPS Yes 13 ppm 18 mo Koller et al. (1977)
Mouse BALB/c Adult ↑LPS No 10 −5 –10 −3 M 2–3 days Shenker et al. (1977)