Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX5-153
Table AX5-9.5. Effect of Lead on Mitogen-induced Lymphoid Proliferation
Species Strain/ Gender Age Proliferation Effects
In Vivo/
Ex Vivo Lead Dose/ Concentration
Duration
of Exposure References
Human C Adult ↓PHA Yes Not available Occupational Mishra et al. (2003)
Mouse TO males Adult ↓ConA
↓LPS
Mouse Several Adult PHA stimulation No
change
Rat Lewis and F344
males
Adult ↑ConA
↑LPS
Yes 1 mg/kg daily 2 wks Fernandez–Carbezudo et al.
(2003)
No 25 µM 3 days McCabe et al. (2001)
No 25 ppm 3 days Razani–Boroujerdi et al. (1999)
Mouse CBA/J Adult LPS No change No 10 µM 3 days McCabe and Lawrence (1990)
Rat AP strain males Adult PHA No change Yes 100 ppm and 1,000 ppm 2–20 wks Kimber et al. (1986)
Mouse CBA/J females Adult ConA
LPS
No change
Mouse BDF1 females Adult ↑ConA
↑PHA
↑Staph A enterotoxin
LPS no change
Rat SD males Adult ↑ConA
↑PHA
↑LPS
Mouse CBA/J females Adult PHA no change
↓LPS (high doses only)
Mouse CBA/J females Adult ConA, PHA no change
↑LPS
Mouse CBA/J females Adult ConA, PHA no change
↑LPS
No 10 −4 M 2 days Warner and Lawrence (1986)
Yes 0–1,000 ppm 3 wks Blakley and Archer (1982)
Yes 1% Pb acetate in diet 2 wks Bendich et al. (1981)
Yes 10 mM 4 wks Lawrence (1981a)
No 10 −6 –10 −4 M 2.5 days Lawrence (1981b)
No 10 −6 –10 −4 M 2–5 days Lawrence (1981c)