Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX5-151
Table AX5-9.3. Studies Reporting Lead-induced Suppression of Delayed Type Hypersensitivity and Related Responses
Species Age Strain/Gender Route Lowest Effective Dose
Duration
of Exposure Reference
Rat Embryo SD females Oral to Dam 250 ppm (BLL at 4 wk = 6.75 µg/dL) 5 wks Chen et al. (2004)
Chicken Embryo Cornell K females in ovo 200 µg Single injection E12 Lee et al. (2002)
Rat Fetal CD females Oral to Dam 500 ppm 6 days Bunn et al.
(2001c)
Rat Embryo–fetal F344 and CD females Oral to Dam 250 ppm 3 wks Bunn et al.
(2001b)
Rat Embryo–fetal F344 females Oral to Dam 250 ppm (BLL = 34.8�µg/dL at birth) 3 wks Bunn et al.
(2001a)
Chicken Embryo Cornell K females in ovo 200 µg (BLL = 11 �µg/dL) Single injection E12 Lee et al. (2001)
Mouse Adult BALB/c females Oral 512 ppm (BLL = 87� µg/dL) 3 wks McCabe et al.
(1999)
Rat Embryo-fetal F344 females Oral to Dam 250 ppm Pb acetate 5 wks (2 before, 3
during gestation)
Rat Embryo-fetal F344 females Oral to Dam 250 ppm Pb acetate 5 wks (2 before, 3
during gestation)
Chen et al. (1999)
Miller et al.
(1998)
Goat Adult Females Gastric intubation 50 mg/kg Pb acetate 6 wks Haneef et al.
(1995)
Rat Adult Wistar males Oral 6.3 m mol kg -1 8 wks Kumar et al.
(1994)
Mouse Adult Swiss s.c. 0.5 mg/kg/d Shortest = 3 days
just prior to
challenge
Laschi-Loquerie
et al. (1984)
Rat Neonatal/ Juvenile CD females Oral 25 ppm Pb acetate (BLL= 29.3 µg/dL) 6 wks Faith et al. (1979)
Mouse Adult BALB/c i.p. 0.025 mg Pb acetate 30 days Muller et al.
(1977)