Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX5-150
Table AX5-9.2. Effect of Lead on Antibody Forming Cells (In Vitro Stimulation)
Species Strain/Gender Age Effect
In Vivo/ Ex
Vivo
Lead Dose/
Concentration
Duration
of Exposure Reference
Mouse Various Adult ↑AFC No 10 µM 5 days McCabe and
Lawrence (1991)
Mouse Various Adult AFC No change Yes 10 mM in water 8 wks Mudziuski et al.
(1986)
Mouse CBA/J females Adult ↑AFC primary response No 100 µM 5 days Warner and
Lawrence (1986)
Mouse BDF1 females Adult ↑AFC—T dependent antigen
AFC—T independent antigen, no
change
Mouse CBA/J females Adult ↑AFC Yes 0.08 mM and
0.4 mM
50 µg Pb acetate in water 3 wks Blakley and
Archer (1981)
4 wks Lawrence (1981a)
Mouse CBA/J Adult ↑AFC No 10 −5 M 5 days Lawrence (1981b)
Mouse CBA/J females Adult ↑AFC No 10 −4 M 1 hr preincubation Lawrence (1981c)
Mouse Swiss males Adult ↓AFC Yes 0.5 ppm tetraethyl Pb 3 wks Blakley et al.
(1980)
Mouse Swiss Adult ↓AFC Yes 1300 ppm 10 wks Koller and Roan
(1980)
Rat SD Neonate–
Juvenile
Mouse Swiss Adult ↑AFC–IgM
↓AFC–IgG
Mouse Swiss Adult ↓AFC–IgM
↓AFC–IgG
↓AFC (IgM) Yes 25 ppm and 50 ppm 3 wks prenatal and
6 wks postnatal
Luster et al (1978)
Yes 4 mg i.p. or oral Single dose Koller et al.
(1976)
Yes 13.75 ppm–1,375 ppm 8 wks Koller and
Kovacic (1974)