Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX5-149
Nature of
Exposure
Occupational 33.2 µg/dL in Pb-exposed
group
2.7 µg/dL in controls
Occupational 10 Pb exposure workers vs.
controls
Worker BLLs of 41–50 µg/dL
No controls >19 µg/dL
Occupational Blood Pbs 64 µg/dL
Range 21–90
Table AX5-9.1 (cont’d). Studies on Lead Exposure and Immune Effects in Humans
Dose or Blood Lead
Levels (BLLs) Sample Population Reported Effects Reference
Occupational Comparison of workers with
25–53 µg/dL vs. controls with
8–17 µg/dL
Environmental Near smelter BLLs varied
seasonally 25–45 µg/dL
Control area BLLs varied
seasonally 10–22 µg/dL
Occupational Workers (18–85.85.2 µg/dL
BLL)
controls (6.6–20.8 µg/dL BLL)
Environmental 12 Afr.- American children
BLLs 41–51µg/dL;
7 controls BLLs 14–30 µg/dL
10 Male workers in scrap metal
refinery vs. 10 controls
39 male workers in Pb exposed
group
PMN chemotaxis reduced to 2 different chemoattractants. Valentino
et al. (1991)
ConA-generated suppressor cell production—increased.
Some other cellular parameters unchanged.
Cohen et al.
(1989)
PHA response of lymphocytes from workers decreased. Alomran and
Shleamoon
(1988)
Workers exposure to Pb No change in serum Ig levels PHA response of cells or NK activity. Kimber et al.
(1986)
Boys and girls ~11.5 yrs old living
near Pb smelting plant
Higher BLL associated with: decreased )-amino levulinic acid dehydrogetase.
Decreased IgM and secretory IgA.
Inversely related to IgG.
73 workers vs. 53 controls Negative correlation of BLL and serum IgG and C3.
Positive correlation of BLL and saliva IgA.
12 African American preschool
children vs. 7 controls
Wagnerova
et al. (1986)
Ewers et al.
(1982)
No difference in anti-tetanus antibody levels or in complement levels. Reigart and
Graber (1976)