Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX5-142
Table AX5-8.5. Uptake of Lead by Teeth
Compound
Dose/Concentration
Duration Exposure
Route Species Effects Blood Level Reference
Pb acetate
1 µg/kg body weight
Single IP injection
Pb aerosol
77, 249, or 1546 µg/m 3
for 50 to 70 days
Inhalation
Pb acetate
0, 3, or10 ppm
During pregnancy and
21 days of lactation
Drinking water
Abbreviations
µg—microgram
kg—kilogram
IP—intraperitoneal
%—percent
h—hour
Rat Uptake of Pb label into incisors of suckling rats:
0.7% of injected dose in 4 incisors of suckling rat after 24 h,
1.43% after 192 h. 0.6% of injected dose in 4 incisors of adult after 24 h,
0.88% after 192 h.
Rat 11 micrograms Pb/g incisor taken up in animals exposed to 77 µg/m 3 for
70 days vs. 0.8 µg Pb/g in control animals
13.8 µg Pb/g incisor in rats exposed to 249 µg/m 3 for 50 days
153 µg Pb/g incisor in rats exposed to 1546 µg/m 3 for 50 days
Rat Pb concentration in teeth of offspring:
0 ppm group–Incisors (1.3 ppm), 1st molars (0.3 ppm)
3 ppm group–Incisors (1.4 ppm), 1st molars (2.7 ppm)
10 ppm group–Incisors (13.3 ppm), 1st molars (11.4 ppm)
m 3 —cubic meter
Pb—lead
g—gram
ppm—parts per million
Mean percent of dose after
time:
Suckling:
3.04% after 24 h
1.71% after 72 h
1.52% after 144 h
1.18% after 192 h
Adult:
6.40% after 24 h
3.41% after 24 h
1.92% after 24 h
1.04% after 72 h
0.72% after 144 h
0.48% after 192 h
Control: 2.6 µg/dL
77 µg/m 3 : 11.5 µg/dL
249 µg/m 3 : 24.1 µg/dL
1546 µg/m 3 : 61.2 µg/dL
Momčilović and
Kostial (1974)
Grobler et al. (1991)
Not given Grobler et al. (1985)