Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX5-123
Table AX5-8.1 (cont’d). Bone Growth in Lead-exposed Animals
Compound
Dose/Concentration
Duration Exposure
Route Species Effects Blood Level Reference
Pb acetate
Hi Pb animals 5000
ppm for 6 mo, reduced
to 1000 ppm;
Lo Pb animals 100 ppm
Drinking Water
Pb acetate
17 mg per kg of feed
50 days
In diet
Pb acetate
17 mg per kg of feed
50 days
In diet
Rat In male rats exposed to 100 ppm Pb in drinking water and a low
calcium diet for up to one yr, bone density was significantly decreased
after 12 mo, while rats exposed to 5000 ppm Pb had significantly
decreased bone density after 3 mo. Pb content of femurs was
significantly elevated over the content of control rats at all time points
(1, 3, 6, 9, 12 mo). Trabecular bone from the low dose animals was
significantly decreased from 3 mo forward.
Rat No differences in the length of the femurs, but the mean length of the
5th lumbar vertebra was significantly decreased. The mean length of
the femur growth plate cartilage was also significantly decreased in Pbexposed
animals.
Rat No differences in the length of the femurs, but the mean length of the
5th lumbar vertebra was significantly decreased. The mean length of
the femur growth plate cartilage was also significantly decreased in Pbexposed
animals.
Low Pb (µg%):
1 mo
Control = 2 ± 1; Exp = 19 ± 10*
3 mo
Control = 2 ± 1; Exp = 29 ± 4*
6 mo
Control = 3 ± 1; Exp = 18 ± 2*
9 mo
Control = 1 ± 1; Exp = 17 ± 3*
12 mo
Control = 3 ± 1; Exp = 21 ± 3*
Hi Pb (µg%):
1 mo
Control = 3 ± 1; Exp = 45 ± 13*
3 mo
Control = 3 ± 1; Exp = 90 ± 15*
6 mo
Control = 4 ± 1; Exp = 126 ± 10*
9 mo
Control = 4 ± 1; Exp = 80 ± 39*
12 mo
Control = 3 ± 1; Exp = 59 ± 18*
*p < 0.001
Gruber et al. (1997)
Not given González-Riola et al.
(1997)
Not given Escribano et al. (1997)