Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX5-117
Table AX5-7.3. Chelation with DMSA
Author Animal Species Lead Dosage Blood Lead Findings
Cory-Slechta
(1988)
Pappas et al.
(1995)
Smith and Flegal
(1992)
Varnai et al.
(2001)
Rats 50 ppm Pb acetate for 3–4 mo 20 µg/dL-Pb
Sprague-Dawley
rats
Wistar rats
Wistar rats
(suckling)
550–1100 ppm Pb acetate for
35 days
206 Pb 210 ng/mL for 1.5 days
DMSA 20 mg/kg i.p.
2 mg/kg/d for 8 days
DMSA 0.5 mmol/kg 6x/d on d1-3
and 6–8
1 µg/dL-Pb+25 mg/kg
DMSA
52 µg/dL @ 550 ppm Pb
65 µg/dL @ 1100 ppm Pb
5.1 ng/g-ctrl
3.0 ng/g-DMSA
—
DMSA 25–50 mg/kg i.p. for 1–5 days mobilized Pb from
blood, brain, kidney and liver, but not femur.
DMSA @16–240 mg/kg/d p.o. for 21 days given with and
without concurrent Pb exposure. Rats showed dose-related
reduction in Pb content of blood, brain, femur, kidney, and
liver with or without concur Pb.
Rats on low Pb diet given DMSA decreased soft tissue but not
skeletal Pb. Pb redistributed to skeleton.
DMSA reduced Pb concentration in carcass, liver, kidneys, and
brain by ~50%.