Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX5-113
Table AX5-7.1 (cont’d). Light Microscopic, Ultrastructural, and Functional Changes
Author Animal Species Lead Dosage Blood Lead Findings
Vyskocil et al.
(1989)
Vyskocil et al.
(1995)
Vyskocil and
Cizkova (1996)
Sanchez et al.
(2001)
Herak-
Kramberger et al.
(2001)
Fujiwara et al.
(1995),
Kaji et al. (1995b)
Wistar rat 0.5%, 1%, and 2% Pb acetate for
2–3 mo
0.5%–105 µg/dL
1%–196 µg/dL
2%–320 µg/dL
Wistar rat 1% or 0.1% Pb acetate for 2–4 mo 1%–173 µg/dL
0.1%–37.6 µg/dL
Wistar rats Unleaded petrol vapor (4mg/m 3 )
8 hrs/day for 60 days
Sprague-Dawley
rat
Rat brush border
membranes
Bovine cultured
vascular smooth
muscle and
endothelial cells
0.06% Pb acetate for 4 mo 13.9 µg/dL vs.