Air Quality Criteria for Lead Volume II of II - (NEPIS)(EPA) - US ...

AX5-42
Citation
Pinon-
Lataillade
et al. (1995)
Pillai and
Gupta (2005)
Ronis et al.
(1996) †
Ronis et al.
(1998a) †
Ronis et al.
(1998b) †
Table AX5-4.1 (cont’d). Effect of Lead on Reproduction and Development in Mammals Effects on Offspring
Species/
Strain/Age
Mouse/NMRI,
adult
Rat/Charles
Foster,
200–220 g
Rat/Sprague-
Dawley, 22,
55 days or plugpositivetimeimpregnated
Rat/Sprague-
Dawley, various
ages
Rat/Sprague-
Dawley, adult
Dose/Route/
Form/Duration Endpoint
0–0.5% Pb acetate in
drinking water exposed to Pb
during gestation until post-
GD 60
Subcutaneous injection of
0.05 mg/kg-d Pb acetate for
5–7 days prior to mating
through PND 21
0.6% Pb acetate in drinking
water for various durations:
PND 24–74 (pubertal
exposure), PND 60–74 (post
pubertal exposure); 11 males
and females in pubertal
exposure group (10 each in
control pubertal group);
6 males and females postpubertal
exposure and control
groups
0.6% Pb acetate in drinking
water ad libitum for various
durations: GD 5 to PND 1,
GD 5 to weaning, PND 1 to
weaning
3 control litters, 2 gestation
exposure litters, 2 lactation
exposure litters, 2 gestation
and lactation exposure litters,
2 postnatal litters, 2 chronic
litters (4 male and 4 female
pups per litter)
Pb acetate in drinking water
(0.05% to 0.45% w/v); dams
exposed until weaning,
exposure of pups which
continued until PND 21, 35,
55, or 85; 5 control litters
(0%), 10 low-dose litters
(0.05%), 8 mid-dose litters
(0.15%), 9 high-dose litters
(0.45%); 4 male and 4 female
pups per litter
Blood Lead Concentration
(PbB)
Pb exposure during gestation reduces litter size; reduced birth weight and growth rates. PbB 200 µg/dL.
Group: pup PbB
Naïve: ~6 µg/dL
Control: 100 µg/dL and reached up to
388 µg/dL.