Giovanni B Frisoni CURRICULUM VITAE - centro alzheimer

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“Google for brain imaging”, where neuroscientists worldwide will be able to find the world’s largest image databases on Alzheimer’s, algorithm tools to extract diagnostic and progression tracking markers, and adequate computational resources. This vision has been further strengthened with the IMI PHARMACOG – Prediction of Cognitive Properties of New Drug Candidates for NeuroDegenerative Diseases in Early Clinical Development project. This is a € 22M study where I am leading the largest workpackage (€ M 4.5) on the development of markers for disease modifying drugs in humans, representing the final success of developing a large ADNI‐based study in Europe (European ADNI). The image data that will be collected in the context of the PHARMACOG‐European ADNI initiative will contribute to further expand the base of data that neuGRID (and what will come after neuGRID) can accommodate and process. In this period, I have carefully kept thriving my traditional line of research on Alzheimer’s and cognitive disturbances. I have been the first Italian to publish on amyloid imaging (#P188 in Neurology), the only with a say in major journals (#E7) despite amyloid imaging has not yet landed in Italy, the first to show evidence of validity of the new revised criteria for the diagnosis of Alzheimer’s disease worldwide (#P197), and, to the best of my knowledge, the first to test the new revised criteria in a clinical service (the “Translational Outpatient Memory Clinic” at the IRCCS‐FBF) (#P197). I have given further fuel to my translational approach to the early diagnosis of Alzheimer’s with the launch of an international effort aimed at developing standardized operational procedures for the measurement of hippocampal atrophy (Harmonization of Protocols for the Manual Tracing of the Hippocampus Development and Validation of a Unified Standard Protocol: An EADC‐ADNI Joint Effort), whose vision is to turn hippocampal volumetry from a diagnostic procedure feasible in few highly specialized research setting into a routinely applicable diagnosic exam. With the appointment as Head of the Psychogeriatric Ward in 2005, I have opened a new line of research on psychiatric diseases. The clinical population of the ward is made of scientifically dejected patients, i.e. psychiatric patients (mainly schizophrenics) over 65 years of age, with decades of the most diverse pharma and non‐pharma treatments. By applying the analytical tools successfully used in patients with neurodegenerative disorders, I have been able to describe their brain structural features in a paper published in Biological Psychiatry (#P189), and more manuscripts are currently in preparation. Moreover, thanks to the use of a creative approach to study hundreds of healthy persons with MR imaging, my research group has described the structural features of a normal personality trait, i.e. alexithymia (#P167). 8. CLINICAL Clinical positions 2005‐2010: Head of the Psychogeriatric Ward at the IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico – Scientific Institute of Research and Care) Fatebenefratelli Hospital, Brescia – FBF, a long‐ term 40‐bed ward devoted to elderly psychiatric patients with behavioral disturbances. The medical staff is made of trained and specialized physicians (2 psychiatrists and one geriatrician). 2000‐2004: temporary interruption of clinical duties following a request from the Scientific Direction of the IRCCS‐FBF to devote up to 85% of my time to research, aiming to foster domestic scientific productivity. In this period, I have continued seeing outpatients 2 half days per week. 6
1991‐1999: Head of the Day Hospital at IRCCS‐FBF, a diagnostic and rehabilitation service with 15 patients with cognitive impairment daily. During this period I was fully in charge of patients and could count on the help of between 1 and 3 residents. 1991: founding staff neurologist of the Alzheimer's Unit at the then Istituto Sacro Cuore Fatebenefratelli, now IRCCS Fatebenefratelli. The Alzheimer's Unit was the first Italian Alzheimer’s Clinic and was funded by the regional government of the Regione Lombardia for its first 7 years of operation, after which it gained IRCCS status and was funded by the Italian Ministry of Health. Its mission is to develop innovative diagnostic, therapeutic, and rehabilitative protocols for patients with Alzheimer’s and psychiatric diseases. 9. ADMINISTRATION I personally develop the budget of my national and international projects, and am in charge opf the budget of my Psychogeriatric Ward. I closely and frequently supervise the work of the administrative secretariats in charge of the budget of my national and international projects, while the routine financial work of the Psychogeriatric Ward is more automated and requires less frequent supervision. 10. PROFESSIONAL SOCIETIES 2010‐to date: Chairman of the NeuroImaging Public Interest Association of ISTAART. 2009‐to date: member of ISTAART, the professional society of the Alzheimer’s Association to promote high standards of care and research in patients with Alzheimer’s and related diseases. 2008‐to date: member of the Executive Committee of the Neuroimaging Interest group of the ENS – European Neurological Society. 2008‐to date: member of the Executive Committee of the Neuroimaging Working group of the SIN – Italian Society of Neurology and in charge of its website (www.neuroimmagini.it). 2000‐to date: member of the Italian Association of Neuroradiology (AINR – Associazione Italiana di Neuroradiologia). 1992‐to date: member of the Italian Society of Geriatrics and Gerontology (SIGG – Società italiana di Geriatria e Gerontologia). 1986‐to date: member of the Italian Society of Neurology (SIN – Società Italiana di Neurologia). 11. TECHNICAL AND SCIENTIFIC ROLES 2010: Issue Editor of the Special Issue of NeuroBiology of Aging on ADNI studies. 2009‐to date: Imaging Section Editor of Neurobiology of Aging. Editor of the upcoming special issue on ADNI studies. 2008‐to date: I have served as a reviewer for a number of projects submitted for funding to the European Commission and as expert for the development of calls in HEALTH and ICT. 2003‐to date: Coordinator of the Neuroimaging Interest Group of the EADC – European Alzheimer’s Disease Consortium, the network of EU academic Alzheimer’s Centres. 2003‐to date: Scientific Coordinator of the Northern Italy branch of the AFaR – Associazione 7
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Giovanni B Frisoni CURRICULUM VITAE - centro alzheimer

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