Giovanni B Frisoni CURRICULUM VITAE - centro alzheimer

More documents

Recommendations

Info

the scientific and clinical community has been increasing steadily over time. While the crude number of publications shows a trend to increase over time, but with a couple of peaks and draughts due to local circumstances (left graph), thanks to the increasingly accurate choice of scientific journals, citations have increased steadily at an exponential rate from 1991 to date (right graph). Scientific biography My scientific biography can be divided into 4 periods: the early times, the “geriatric” period, the “Alzheimer’s” period, and the “European” period. The early times (late eighties to early nineties). This is the period between graduation at the general medicine and neurological specialty school (1986 to 1990), when I published as the first author his first full paper on a the case of a young man with disulfiram polyneuropathy and review of the literature (ref #R1). The general medicine and neurological specialty dissertations found space in Behavioral Brain Research (second author) and Stroke (first author), respectively (ref #P5 and P3). While attending my residency in neurology, I observed a couple of peculiar neurological cases whom I described (#P2, P4). Notably, under the Italian educational system, there were no obligation to publish scientific manuscripts neither for dissertations nor residency. I did this for the mere pleasure of understanding what was happening to my patients and hopefully be able to help them more effectively. The “geriatric” period (mid to late nineties). In 1989 I joined the group of Marco Trabucchi, former President of the Italian Geriatric Society, under whose leadership I started entertaining interests in cognitive disturbances and geriatric topics at large, publishing as a first author in the major geriatric journals J Am Geriatrics Soc, (#P14) and J Gerontol (#P9, P21) and contributing statistical and clinical expertise to a large number of studies on disability, falls, nutrition, comorbidity, frailty, caregiver issues, quality of life, insight, organizational research, and cognitive and physical rehabilitation. In 1997 I was scientific coordinator of the EU‐funded study SCUD – The Special Care Units for Demented: a Controlled Study of Effectiveness. In this period, the two main areas of personal interest were apoE and imaging. I have been the first to report on the association between apoE and vascular dementia (#L5 in JAMA), of apoE with rate of disease progression (#P20 in Ann Neurol), and the first to study apoE in dementia in Italy. Due to limitations on the technical facilities available in my institution at that time, I closed my line of research on apoE and marked this with an editorial in the JNNP (#E1). My first functional and structural imaging 4
studies were aimed to standardize the then exquisitely subjective reading of imaging exams (e.g. #P28 in AJNR) and use imaging tools to improve diagnostic accuracy (e.g. #P31 in JNNP and P46 in Neurology). On these issues, I was the pioneer in Italy and have summarized my achievements in the field of imaging with non computational tools in an editorial appeared in the JNNP (#E2). The “Alzheimer’s” period (late nineties to mid‐2000). In 1999, with the birth of the LENITEM, my scientific interests have veered more strongly towards the translational application of imaging techniques in the clinic. In the very early times of computational neuroscience, I have been the first in Italy to apply voxel‐based morphometry to neurological patients (#P79) and adopt the more sophisticated methods of cortical and hippocampal mapping (#R7 in Lancet Neurol, P127 in NeuroImage, and P141 in Brain). In this period, I have taken the lead of the Neuroimaging Interest Group of the EADC – European Alzheimer’s Disease Consortium and produced a European consensus document on the use of neuroimaging tools to rate key imaging features (#R8), brought the ADNI methods for multicentre MR image acquisition from the US to Europe (#P164), and investigated the diagnostic and therapeutic procedures of Italian dementia expert centres (#P177, P154, P133, P109, P87). Lastly, I have summarized the relevant advances in dementia research of the year 2006 in the January 2007 issue of The Lancet Neurology (#E6). In 2003 I have been appointed Scientific Coordinator of AFaR – Associazione Fatebenefratelli per la Ricerca. This is the scientific branch of the 25 Fatebenefratelli (Religious Order of St John of God) health services in Italy. My mission was to promote evidence‐based medical care in the pilot Fatebenefratelli hospital of San Maurizio Canavese, in the Turin area, where I have set up all the necessary procedures and trained personnel to the early diagnosis of Alzheimer’s and other cognitive disorders with the innovative use of imaging biomarkers (medial temporal and hippocampal atrophy based on high resolution MR). Since then, physicians in charge use hippocampal volumetry as part of their clinical assessment. The “European period” (late‐2000). From 2005, I decidedly entered the arena of European projects. I led my first FP project as a Principal Investigator in 2005 (ENIR – European NeuroImaging Repository, www.centroalzheimer.it/ENIR.doc), aiming to develop the theoretical foundations for a Europe‐wide infrastructure capable of storing and processing a vast amount of brain imaging data with sophisticated computational algorithms. In that same year, talks were started between the European Alzheimer’s Disease Consortium and the US ADNI – Alzheimer’s Disease Neuroimaging Initiative (www.adni‐ info.org) to explore the latitude for an extension of the ADNI to Europe, and I obtained funds from the US Alzheimer’s Association to carry out the Pilot European Alzheimer’s Disease Neuroimaging Initiative (pilot E‐ADNI) in 7 Alzheimer’s centres throughout Europe (http://www.centroalzheimer.it/E‐ ADNI_project.htm) in close connection with US ADNI. In 2008 I obtained a € 2.8 M funding from FP7 for neuGRID ‐ A Grid‐Based e‐Infrastructure for Data Archiving/Communication and Computationally Intensive Applications in the Medical Sciences (www.neuGRID.eu). The project successfully concluded in January 2011, creating the necessary conditions for two expansions: outGRID, a € 440 K project funded under EC FP7 (www.outGRID.eu) aiming to make neuGRID interoperable with homologous infrastructures in the US and Canada and neuGRID for users (N4U) which aims to provide neuroscientists with a Global Virtual Laboratory by further developing and deploying the neuGRID infrastructure. The long term vision is to develop the 5
Page 1 and 2: 1. PERSONAL DATA Giovanni B Frisoni
Page 3: � July 2010: Chairman of the Alzh
Page 7 and 8: 1991‐1999: Head of the Day Hospit
Page 9 and 10: Ministry of Health. � 2008: Princ
Page 11 and 12: � 1998: Universita’ Cattolica d

Giovanni B Frisoni CURRICULUM VITAE - centro alzheimer

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?