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Environmental Health Criteria 214

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HUMAN EXPOSURE ASSESSMENT<br />

9.2.3.2 Immunochemical assays of dust mite<br />

allergens<br />

9.2.3.3 Guanine determination<br />

9.2.4. Mite allergens<br />

9.3. Allergens from pets and cockroaches<br />

9.3.1. Air sampling for allergens from pets and cockroaches<br />

9.3.2. Dust sampling for allergens from pets and<br />

cockroaches<br />

9.3.3. Available methods of analysis<br />

9.3.4. Typical allergen concentrations<br />

9.4. Fungi<br />

9.4.1. Air sampling for fungi<br />

9.4.2. Settled dust for fungi<br />

9.4.3. Available methods of analysis for fungi in air<br />

9.4.3.1 Total counts of viable and non-viable<br />

fungal particles<br />

9.4.4. General considerations for fungi<br />

9.5. Bacteria (including actinomycetes)<br />

9.5.1. Air sampling for bacteria<br />

9.5.2. Dust sampling for bacteria<br />

9.5.3. Available methods of analysis for bacteria<br />

9.5.3.1 Total count of viable and non-viable<br />

bacteria<br />

9.5.3.2 Viable bacteria<br />

9.5.3.3 Endotoxins<br />

9.6. Pollen<br />

9.6.1. Air sampling for pollen<br />

9.6.2. Dust sampling for pollen<br />

9.6.3. Available methods of analysis for pollen in air<br />

9.6.4. General considerations for pollen sampling<br />

9.7. Summary<br />

10. ASSESSING EXPOSURES WITH BIOLOGICAL MARKERS<br />

10.1. Introduction<br />

10.2. General characteristics<br />

10.3. Considerations for use in environmental exposure assessment<br />

10.3.1. Toxicokinetics and toxicodynamics<br />

10.3.2. Biological variability<br />

10.3.3. Validation of biological markers<br />

10.3.4. Normative data<br />

10.4. Advantages of biological markers for exposure assessment<br />

10.4.1. Characterizing inter-individual variability<br />

10.4.2. Efficacy of use<br />

10.4.3. Internal exposure sources<br />

10.5. Limitations of biological markers for exposure assessment<br />

10.5.1. Source identification<br />

10.5.2. Biological variability and altered exposure response<br />

10.5.3. Participant burden<br />

10.5.4. Biosafety<br />

10.6. Media available for use<br />

10.6.1. Blood<br />

10.6.2. Urine<br />

10.6.3. Exhaled breath<br />

10.6.4. Saliva<br />

10.6.5. Keratinized tissue (hair and nails)<br />

10.6.6. Ossified tissue<br />

10.6.6.1 Teeth<br />

10.6.6.2 Bone<br />

http://www.inchem.org/documents/ehc/ehc/ehc<strong>214</strong>.htm<br />

Page 6 of 284<br />

6/1/2007

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