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Environmental Health Criteria 214

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HUMAN EXPOSURE ASSESSMENT<br />

of the environmental health paradigm also showing the role of exposure<br />

is depicted in Fig. 2. The role of exposure assessment in the risk<br />

assessment framework applied by EU and US EPA is shown in Fig. 3.<br />

The release of an agent into the environment, its ensuing<br />

transport, transformation and fate in various environmental media, and<br />

its ultimate contact with people are critical events in understanding<br />

how and why exposures occur. Definitions for key events in the<br />

continuum are summarized below. They were compiled from three sources:<br />

Ott (1990); US EPA (1992a); Sexton et al. (1995a).<br />

* Sources. The point or area of origin for an environmental agent<br />

is known as a source. Agents are released into the environment from<br />

a wide variety of sources, which are often categorized as<br />

primary sources including point sources (e.g., incinerator)<br />

versus area sources (e.g., urban runoff), stationary sources (e.g.,<br />

refinery) versus mobile sources (e.g., automobile) and<br />

anthropogenic sources (e.g., landfill) versus non-anthropogenic<br />

sources (e.g., natural vegetation) and secondary sources<br />

including condensation of vapours into particles and chemical<br />

reactions of precursors producing new pollutants.<br />

* Exposure pathway. An exposure pathway is the physical course<br />

taken by an agent as it moves from a source to a point of contact<br />

with a person. The substance present in the media is quantified as<br />

its concentration.<br />

http://www.inchem.org/documents/ehc/ehc/ehc<strong>214</strong>.htm<br />

Page 24 of 284<br />

6/1/2007

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