New Modes of GPCR Signalling

More documents

Recommendations

Info

Rapid Detection of Deletion of the PMP22 Gene from a Kindred in China with Hereditary Neuropathy with Liability to Pressure Palsy by Real-time Quantitative PCR Yuan He1, Qiang Wu2, Qianqian Wang1, Wanhong Liu1* and Xiaohua He1* 1School of Medicine, Wuhan University, Wuhan 430071, China 2Wuhan General Hospital, Wuhan 430072, China The hereditary neuropathy with liability to pressure palsy (HNPP) is an autosomal-dominantly inherited peripheral neuropathy, and the deletion of the peripheral myelin protein (PMP22) gene in chromosome 17p11.2-12 is the main cause for it, accounting for approximately 70% of all cases. In this study we reported the clinical phenotypes and electrophysiological findings from one patient in a kindred in china who was affected by HNPP. At the same time, the deletion of PMP22 gene which came from two patients and six asymptomatic normal members in the same kindred was studied by real-time quantitative PCR using SYBR Green I. The copy number of the PMP22 gene was determined by the comparative threshold cycle method and the albumin was used as a reference gene. This study disclosed that the PMP22 gene from two patients did deleted, which was the same as the previous report in other nations, and six asymptomatic normal members had no deletion except two members. We conclude the two asymptomatic members with deletion of the PMP22 gene might develop some relative symptoms one day. Key Words: HNPP; Peripheral neuropathy; PMP22; Real-time quantitative PCR Acknowledgment: This work was supported by Program for New Century Excellent Talents, Wuhan University (No. NCET-07-0630),the Scientific Research Foundation for the Returned Overseas Chinese Scholars in State Education Ministry, and Research Fund for the Doctoral Program of Higher Education of China (No. 20090141110010). *Corresponding author E-mail: liuwanhong@whu.edu.cn or hexiaohua@whu.edu.cn
Therapeutic Effect of Flupirtine on Repetitive Febrile Seizures Rats Yanlan Liu, Fang Yu, Biwen Peng, Yuncui Wang, Wanhong Liu, Xiaohua,He* School of Medicine, Wuhan University, Wuhan 430071, China Aim:KCNQ2 and KCNQ3 encode subunits of neuronal M-type K + channels,which are key regulators of brain excitability.This study tests whether Flupirtine , a selective KCNQ2 activator ,is effective in the experimental model of repetitive febrile seizures. Methods: Our study includes 40 male Sprague-Dawley (SD) rats at postnatal day 10 (P10) divided into normal、febrile seizures、phenobarbital and flupirtine groups. We induced repetitive febrile seizures starting at postnatal day 10 (P10) with hot water bath(45.0 ℃ ) for 8 consecutive days. In phenobarbital and flupirtine groups, phenobarbital and flupirtine at the dose 30mg/kg b.m. was administered respectively 2 hours before febrile seizures . febrile seizures group and normal group rats received only normal saline. At P28, we induced febrile seizures again to test the rats' susceptivity to febrile seizures. At P30, the Morris water maze were applied to measure the rats’ learning and memory abilities in each group. Thereafter, hippocampal slices were prepared for histological and morphometric examination. Results: Both Flupirtine and phenobarbital can significantly increase the latency and decrease the rate and duration of febrile seizures when administered before FS(P
Page 1 and 2:
INVITED LIST OF INVITED SPEAKER’S
Page 3 and 4:
LIST OF SOLICITED ABSTRACT Chemosen
Page 5 and 6:
................................105
Page 7 and 8:
INVITED SPEAKER’S INFO Prof. Joë
Page 9 and 10:
ABSTRACT New Modes of GPCR Signalli
Page 11 and 12:
carcinogenesis in mice. Nature Gene
Page 13 and 14:
INVITED SPEAKER’S INFO Prof. Jean
Page 15 and 16:
ABSTRACT Sensing mGlu Receptor Acti
Page 17 and 18:
metabotropic glutamate-like recepto
Page 19 and 20:
INVITED SPEAKER’S INFO Prof. Deni
Page 21 and 22:
ABSTRACT Manipulation of Rac Activi
Page 23 and 24:
Activity-based Probe for Specific P
Page 25 and 26:
INVITED SPEAKER’S INFO Prof. Yong
Page 27 and 28: ABSTRACT From Bench to Bedside: BAC
Page 29 and 30: photoreceptor cell specific protein
Page 31 and 32: INVITED SPEAKER’S INFO Prof. Huax
Page 33 and 34: ABSTRACT Novel Genes and Pathways t
Page 35 and 36: and Jiuping Ding. A residue at the
Page 37 and 38: INVITED SPEAKER’S INFO Prof. Jian
Page 39 and 40: ABSTRACT The Synaptic Mechanisms of
Page 41 and 42: melastatin, a TRP-related protein,t
Page 43 and 44: INVITED SPEAKER’S INFO Prof. Jean
Page 45 and 46: ABSTRACT Spatial Control of Synapti
Page 47 and 48: ROS/RNS generation. Free Radical Bi
Page 49 and 50: INVITED SPEAKER’S INFO Prof. Xi H
Page 51 and 52: ABSTRACT Mechanisms of Wnt Signalin
Page 53 and 54: 7. Zha X-M, Wemmie JA, Welsh MJ (20
Page 55 and 56: INVITED SPEAKER’S INFO Prof. Tao
Page 57 and 58: ABSTRACT Sequential Activation of O
Page 59 and 60: Chemosensory and Behavior of C.eleg
Page 61 and 62: Microvavle Immobilization of Intact
Page 63 and 64: Isoform-Specific Prolongation of KC
Page 65 and 66: UNC-31/CAPS Docks and Primes Dense
Page 67 and 68: Calcium Signaling in Astrocytes Ind
Page 69 and 70: Isolation, Characterization and Ant
Page 71 and 72: Role of Heat on the Expression and
Page 73 and 74: The Kv1.3 Channel Blocker Scorpion
Page 75 and 76: IGF-1 Promote BPH-1 Cell Proliferat
Page 77: Therapeutic Effect of Flupirtine on
Page 81 and 82: Does the Metabotropic Glutamate Rec
Page 83 and 84: Imaging Neuronal Population in Vitr
Page 85 and 86: Phone: 86-27-85351625 A Novel Mutat
Page 87 and 88: MAPK Scaffolding by BIT1 in the Gol
Page 89 and 90: Phosphoinositide-3-Kinase Pathway A
Page 91 and 92: Akt Overexpression Opposes the Beta
Page 93 and 94: Effects of ZD7288 on Long-Term Pote
Page 95 and 96: Embryonic Heart Growth is Regulated
Page 97 and 98: Quantitative Phosphoproteomics Anal
Page 99 and 100: Morphine Regulated Thioredoxin-1 Ex
Page 101 and 102: Investigate the Role of Rab27 in th
Page 103: Effects of Cyclic Nucleotide Gated
show all

New Modes of GPCR Signalling

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?