New Modes of GPCR Signalling
New Modes of GPCR Signalling
New Modes of GPCR Signalling
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Therapeutic Effect <strong>of</strong> Flupirtine on RepetitiveFebrile Seizures Rats<br />
Yanlan Liu, Fang Yu, Biwen Peng, Yuncui Wang, Wanhong Liu, Xiaohua,He*<br />
School <strong>of</strong> Medicine, Wuhan University, Wuhan 430071, China<br />
Aim:KCNQ2 and KCNQ3 encode subunits <strong>of</strong> neuronal M-type K + channels,which are<br />
key regulators <strong>of</strong> brain excitability.This study tests whether Flupirtine , a selective<br />
KCNQ2 activator ,is effective in the experimental model <strong>of</strong> repetitive febrile seizures.<br />
Methods: Our study includes 40 male Sprague-Dawley (SD) rats at postnatal day 10<br />
(P10) divided into normal、febrile seizures、phenobarbital and flupirtine groups. We<br />
induced repetitive febrile seizures starting at postnatal day 10 (P10) with hot water<br />
bath(45.0 ℃ ) for 8 consecutive days. In phenobarbital and flupirtine groups,<br />
phenobarbital and flupirtine at the dose 30mg/kg b.m. was administered respectively 2<br />
hours before febrile seizures . febrile seizures group and normal group rats received<br />
only normal saline. At P28, we induced febrile seizures again to test the rats'<br />
susceptivity to febrile seizures. At P30, the Morris water maze were applied to measure<br />
the rats’ learning and memory abilities in each group. Thereafter, hippocampal slices<br />
were prepared for histological and morphometric examination.<br />
Results: Both Flupirtine and phenobarbital can significantly increase the latency and<br />
decrease the rate and duration <strong>of</strong> febrile seizures when administered before FS(P
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