New Modes of GPCR Signalling
New Modes of GPCR Signalling
New Modes of GPCR Signalling
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Foamy Virus as Potential Vectors for Gene Therapy in Nervous Disorders<br />
and Signal Pathway in Neural Cell Transduction<br />
Ying-Ying ZHANG#, Yong-Juan LIU#, Guo-Guo ZHU, Yan-Yan QIU, Biwen PENG,<br />
Jun YIN, Wan-Hong LIU* and Xiao-Hua HE*<br />
School <strong>of</strong> Medicine, Wuhan University, Wuhan 430071, China<br />
# Equal contribution to this work<br />
Foamy viruses are a type <strong>of</strong> retrovirus with a wide range <strong>of</strong> hosts and non-pathogenicity.<br />
Due to their unique structures, safety and the large packaging capacities, foamy viruses<br />
have been developed into an effective vector system for gene therapy. However, it is<br />
still a controversial issue whether foamy virus vectors could be as exogenous gene<br />
conveyance in the nervous system located a large number <strong>of</strong> growth-arrested cells. In<br />
this review, we focus on this issue and analyze the reasons for their potentiality <strong>of</strong><br />
infecting the growth-arrested cells. Several evidences in papers (from 1997 to 2009)<br />
concerning transduction <strong>of</strong> the growth-arrested cells and neurons by foamy virus vectors<br />
were compared and analyzed. It is demonstrated that foamy virus vectors can transduce<br />
some growth-arrested cells and neurons. Assuredly, further pro<strong>of</strong>s are needed in the<br />
future. However, these facts suggested that foamy viruses may become potential<br />
transfer vectors for gene therapy in nervous disorders and even for signal pathway in<br />
neural cell transduction.<br />
Key Words: foamy virus vectors; growth-arrested cells; neurons; gene therapy;<br />
neuro-signalling transduction<br />
Acknowledgment: This work was supported by National Natural Sciences Foundation<br />
<strong>of</strong> China (No. 30870856 and 30970145), Program for <strong>New</strong> Century Excellent Talents,<br />
Wuhan University (No. NCET-07-0630),the Scientific Research Foundation for the<br />
Returned Overseas Chinese Scholars in State Education Ministry, Research Fund for the<br />
Doctoral Program <strong>of</strong> Higher Education <strong>of</strong> China (No. 20090141110010) and the<br />
Independent Scientific Research Foundation <strong>of</strong> Wuhan University (No.3081002).<br />
*Corresponding author<br />
Tel: 86-27-68759985, Fax: 86-27-68759991.<br />
E-mail: liuwanhong@whu.edu.cn or hexiaohua@whu.edu.cn
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